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[SANET-MG] glyphosate toxic roundup worse
Environmental Health Perspectives Volume 113, Number 6, June 2005
Differential Effects of Glyphosate and Roundup on Human Placental Cells
and Aromatase
Sophie Richard, Safa Moslemi, Herbert Sipahutar, Nora Benachour, and
Gilles-Eric Seralini
Laboratoire de Biochimie et Biologie Moleculaire, USC-INCRA, Université
de Caen, Caen, France
Abstract
Roundup is a glyphosate-based herbicide used worldwide, including on
most genetically modified plants that have been designed to tolerate it.
Its residues may thus enter the food chain, and glyphosate is found as a
contaminant in rivers. Some agricultural workers using glyphosate have
pregnancy problems, but its mechanism of action in mammals is
questioned. Here we show that glyphosate is toxic to human placental
JEG3 cells within 18 hr with concentrations lower than those found with
agricultural use, and this effect increases with concentration and time
or in the presence of Roundup adjuvants. Surprisingly, Roundup is always
more toxic than its active ingredient. We tested the effects of
glyphosate and Roundup at lower nontoxic concentrations on aromatase,
the enzyme responsible for estrogen synthesis. The glyphosate-based
herbicide disrupts aromatase activity and mRNA levels and interacts with
the active site of the purified enzyme, but the effects of glyphosate
are facilitated by the Roundup formulation in microsomes or in cell
culture. We conclude that endocrine and toxic effects of Roundup, not
just glyphosate, can be observed in mammals. We suggest that the
presence of Roundup adjuvants enhances glyphosate bioavailability and/or
bioaccumulation. Key words: adjuvants, aromatase, endocrine disruption,
glyphosate, herbicide, human JEG3 cells, placenta, reductase, Roundup,
xenobiotic. Environ Health Perspect 113:716-720 (2005).
doi:10.1289/ehp.7728 available via http://dx.doi.org/ [Online 25
February 2005]
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