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[SANET-MG] aspartame cancer
First Experimental Demonstration of the Multipotential Carcinogenic
Effects of Aspartame
Administered in the Feed to Sprague-Dawley Rats
Morando Soffritti, Fiorella Belpoggi, Davide Degli Esposti,Luca
Lambertini, Eva Tibaldi, and Anna Rigano
doi:10.1289/ehp.8711 (available at http://dx.doi.org/)
Online 17 November 2005 Environmental Health Prespective
ABSTRACT
The Cesare Maltoni Cancer Research Center of the European Ramazzini
Foundation has
conducted a long-term bioassay on aspartame (APM), a widely used
artificial sweetener.
APM was administered with feed to 8 week-old Sprague-Dawley rats
(100-150/sex/group),
at concentrations of 100,000; 50,000; 10,000; 2,000; 400; 80 or 0 ppm.
The treatment lasted
until natural death, at which time all deceased animals underwent
complete necropsy.
Histopathological evaluation of all pathological lesions and of all
organs and tissues
collected was routinely performed on each animal of all experimental groups.
The results of the study show for the first time that APM, in our
experimental conditions,
causes: 1) an increased incidence of malignant tumor-bearing animals
with a positive
significant trend in males (p0.05) and in females (p0.01), in
particular those females
treated at 50,000 ppm (p0.01); 2) an increase in lymphomas and
leukemias with a positive
significant trend in both males (p0.05) and females (p0.01), in
particular in femalestreated at doses of 100,000 (p0.01), 50,000
(p0.01), 10,000 (p0.05), 2,000 (p0.05),400 (p0.01) ppm; 3) a
statistically significant increased incidence, with a positive
significant trend (p0.01) of transitional cell carcinomas of the renal
pelvis and ureter and their precursors (dysplasias) in females treated
at 100,000 (p0.01), 50,000 (p0.01),10,000 (p0.01), 2,000 (p0.05) and
400 ppm (p0.05); and 4) an increased incidence of malignant schwannomas
of peripheral nerves with a positive trend (p 0.05) in males.
The results of this mega-experiment indicate that APM is a
multipotential carcinogenic
agent, even at a daily dose of 20 mg/kg b.w., much less than the current
acceptable daily
intake (ADI). On the basis of these results, a re-evaluation of the
present guidelines on the use and consumption of APM is urgent and
cannot be delayed.
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