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[SANET-MG] fat people caused by virus



A fat vaccine seems like a good way to deal with world hunger. Cutting back overeating should lead to food surplus? Am J Physiol Regul Integr Comp Physiol 290: R190-R194, 2006. First published September 15, 2005; doi:10.1152/ajpregu.00479.2005

APPETITE, OBESITY, DIGESTION, AND METABOLISM
Adipogenic potential of multiple human adenoviruses in vivo and in vitro in animals
Leah D. Whigham,1 Barbara A. Israel,2 and Richard L. Atkinson1

Departments of 1Medicine and Nutritional Sciences and 2Pathobiological Sciences, University of Wisconsin, Madison, Wisconsin

Submitted 7 July 2005 ; accepted in final form 30 August 2005

Human adenovirus-36 (Ad-36) increases adiposity in chickens, mice, and nonhuman primates and is associated with human obesity. Ad-36 paradoxically reduces serum cholesterol and triglycerides in animal models. Ad-36 increases adipocyte differentiation and triglyceride accumulation in 3T3-L1 cells in vitro. This study evaluated whether three other human adenoviruses increase adiposity in chickens and in 3T3-L1 cells in vitro. We inoculated chickens with human Ad-2, Ad-31, Ad-37, or media at age 3 wk. Food intake and weights were recorded for 3.5 wk, and then chickens were killed and visceral fat, body composition, serum lipids, and viral antibody status were determined. Visceral fat and total body fat were significantly elevated (P < 0.001) in the Ad-37 group compared with all other groups. Final body weights were higher in chickens inoculated with Ad-37 compared with Ad-2, but not significantly higher than in control or Ad-31 groups. Food intake did not differ among groups. Serum cholesterol was elevated in Ad-37 chickens compared with control (P < 0.01) but was not affected by other viruses. Triglycerides were reduced in Ad-37 chickens (P < 0.0001) but were not affected by other viruses. In 3T3-L1 cells in vitro, Ad-31, Ad-36, and Ad-37, but not Ad-2, increased adipocyte differentiation and triglycerides accumulation. In summary, Ad-37 is another human adenovirus that increases adiposity and reduces serum triglycerides in an animal model. However, the response of serum cholesterol is opposite that of Ad-36. Evaluation of other human adenoviruses to determine their effects on adiposity and serum lipids is warranted, but in vitro assays may not be definitive for this purpose.

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