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Re: Herbs to aid genital herpes
On Fri, 14 Jun 1996, Tim Fitzmaurice wrote:
> Yep, found a paper on Zn in anti-herpes therapy.....the compounds listed
> as best Zinc Aspartate and Zinc Picinolate....if people want the cite and
> abstract I'll post it.
OK here's the citations after requests.....Any comments...
Tim
(1) TI: Complexes of zinc with picolinic and aspartic acids inactivate
free varicella-zoster virions
AU: Shishkov_S, Varadinova_T, Bontchev_P, Nachev_C, Michailova_E
JN: Metal-Based Drugs, 1996, Vol.3, No.1, pp.11-14
AB: Zn(II) picolinate and aspartate, Zn(pic)2 and Zn(asp)2, have
been shown to inhibit key steps of the replication of HSV-1. In
the present study we describe the effect of Zn(pic)2 and
Zn(asp)2 on the replication of VZV and on the infectivity of
free virions. The experiments are done using BHK-21 cells, a
clinical isolate of VZV and Zn-complexes in concentration of 10
muM. When Zn-complexes are present during the whole period of
infection, the yield of infectious virus progeny decreases up
to 98%. The infectivity of VZV is completely restored after the
removal of zinc. The virucidal effect is manifested at the 2nd
h of contact, when 90% of the virions are inactivated. The
results show that both Zn(pic)2 and Zn(asp)2 specifically
inactivate free VZV virions with no effect on viral
replication.
[This is the first paper, it covers VZV rather than HSV, but mentions
some effects on HSV]
(2) TI: Mode of action of Zn-complexes on herpes simplex virus type 1
infection in vitro
AU: Varadinova_TL, Bontchev_PR, Nachev_CK, Shishkov_SA,
Strachilov_D, Paskalev_Z, Toutekova_A, Panteva_M
JN: Journal of Chemotherapy, 1993, Vol.5, No.1, pp.3-9
AB: The influence of Zn-complexes with biologically active ligands
like aminoacids: picolinic acid as Zn(pic)2 and asparaginic
acid as Zn(asp)2 on HSV-1 infection in vitro was investigated.
Studies on kinetics of Zn-ions using labeled 65Zn(pic)2 as a
marker, show that at the 45(th) min Zn-ions are exposed onto or
into cells. When cells were infected 60 min after the treatment
with 65Zn(pic)2, 1h later the activity of Zn-ions in the cell
fraction decreased while in the medium increased. This result
shows that soon after the infection cells expelled part of
their Zn. If Zn(pic)2 or Zn(asp)2 are added at the end of the
adsorption period, ICP4 and ICP8 are localized in the cytoplasm
but not in the nucleus of infected cells, while the synthesis
of gH is decreased. A sharply increased number of nucleocapsids
with low electron density cores was also found.
[This paper goes into details of effects in HSV1]
References: