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Re: Herbs to aid genital herpes



On Fri, 14 Jun 1996, Tim Fitzmaurice wrote:
> Yep, found a paper on Zn in anti-herpes therapy.....the compounds listed 
> as best Zinc Aspartate and Zinc Picinolate....if people want the cite and 
> abstract I'll post it.

OK here's the citations after requests.....Any comments...

Tim

(1)   TI: Complexes of zinc with picolinic and aspartic acids inactivate 
          free varicella-zoster virions
      AU: Shishkov_S, Varadinova_T, Bontchev_P, Nachev_C, Michailova_E
      JN: Metal-Based Drugs, 1996, Vol.3, No.1, pp.11-14
      AB: Zn(II) picolinate and aspartate, Zn(pic)2 and Zn(asp)2, have 
          been shown to inhibit key steps of the replication of HSV-1. In
          the present study we describe the effect of Zn(pic)2 and 
          Zn(asp)2 on the replication of VZV and on the infectivity of 
          free virions. The experiments are done using BHK-21 cells, a 
          clinical isolate of VZV and Zn-complexes in concentration of 10
          muM. When Zn-complexes are present during the whole period of 
          infection, the yield of infectious virus progeny decreases up 
          to 98%. The infectivity of VZV is completely restored after the
          removal of zinc. The virucidal effect is manifested at the 2nd 
          h of contact, when 90% of the virions are inactivated. The 
          results show that both Zn(pic)2 and Zn(asp)2 specifically 
          inactivate free VZV virions with no effect on viral 
          replication.
[This is the first paper, it covers VZV rather than HSV, but mentions 
some effects on HSV]

(2)   TI: Mode of action of Zn-complexes on herpes simplex virus type 1 
          infection in vitro
      AU: Varadinova_TL, Bontchev_PR, Nachev_CK, Shishkov_SA, 
          Strachilov_D, Paskalev_Z, Toutekova_A, Panteva_M
      JN: Journal of Chemotherapy, 1993, Vol.5, No.1, pp.3-9
      AB: The influence of Zn-complexes with biologically active ligands 
          like aminoacids: picolinic acid as Zn(pic)2 and asparaginic 
          acid as Zn(asp)2 on HSV-1 infection in vitro was investigated. 
          Studies on kinetics of Zn-ions using labeled 65Zn(pic)2 as a 
          marker, show that at the 45(th) min Zn-ions are exposed onto or
          into cells. When cells were infected 60 min after the treatment
          with 65Zn(pic)2, 1h later the activity of Zn-ions in the cell 
          fraction decreased while in the medium increased. This result 
          shows that soon after the infection cells expelled part of 
          their Zn. If Zn(pic)2 or Zn(asp)2 are added at the end of the 
          adsorption period, ICP4 and ICP8 are localized in the cytoplasm
          but not in the nucleus of infected cells, while the synthesis 
          of gH is decreased. A sharply increased number of nucleocapsids
          with low electron density cores was also found.
[This paper goes into details of effects in HSV1]

References: