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Dissertation Information for Jason Scott Keiper

NAME:
- Jason Scott Keiper

DEGREE:
- Ph.D.

DISCIPLINE:
- Chemistry

SCHOOL:
- Emory University (USA) (2000)

ADVISORS:
- Fred M. Menger

COMMITTEE MEMBERS:
- [Indecipherable1]
- Frank E. McDonald

MPACT Status: Complete - Except Indecipherables

Title: I. Micromanipulation and transformations of giant vesicles. II. Gemini surfactants with acetylenic spacers

Abstract: "Part I . The giant vesicle is becoming an object of intense scrutiny by chemists, biologists, and physicists interested in membrane behavior. Giant vesicles are spherical bilayer assemblies with diameters of 1-500 ìm. Having a size and curvature comparable to living calls, giant vesicles can be regarded as ""cytomimetic""--stripped down skeletons of the actual biological counterpart. Importantly, the size of giant vesicles renders them visible by light microscopy and manipulatable by common cytological techniques. Experiments utilizing micromanipulation to transform giant vesicles are described, including vesicle adhesion, electrostatically-driven membrane layering, saponin-induced disruption, and fluorescence quenching evaluation. The work demonstrates the relevance of the giant vesicle to different fields as well as its versatility as a model membrane.

Part II . A total of 24 di-cationic geminis surfactants were synthesized having a 2-butynyl spacer and chain-lengths varying from 8 to 18 carbons and varying headgroups that included heterocycles. Geminis with more flexible butyl spacers were also synthesized for comparison purposes. Tensiometry provided CMC values, surface activity, and Gibbs areas. Film studies on the C 18 geminis afforded liftoff and collapse areas. The acetylenic geminis behave normally with the log CMC values decreasing linearly with chain-length for all the dibromide salts. Anomalous behavior occurred, however, with the C 18 gemini having a butyl spacer. It was found that CMC data correlate with spacer area, a relationship ascribed to packing constraints on curved surfaces and, possibly, to steric inhibition of ion-binding. The effects are accentuated with the C 18 surfactants."

MPACT Scores for Jason Scott Keiper

A = 0
C = 0
A+C = 0
T = 0
G = 0
W = 0
TD = 0
TA = 0
calculated 2008-04-13 13:55:32

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