Dissertation Information for Allen Bennett CornettNAME:
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SCHOOL: ADVISORS: COMMITTEE MEMBERS: MPACT Status: Fully Complete Title: Solution conformational studies of microtubule-stabilizing agents Abstract: Taxol, a natural product isolated from the bark of the Pacific Yew tree, is widely prescribed for the treatment of ovarian and breast cancer. Despite its clinical efficacy, the compound has a number of undesirable properties, which include neurotoxicity and both acquired and multidrug resistance. Taxol operates by altering the dynamics of microtubules, crucial components of the cellular cytoskeleton. A number of additional natural products with anti-proliferative activity are known to operate by the same mechanism of action. These compounds include epothilone, eleutherobin, and discodermolide. As part of research aimed at the design of new therapeutic agents with improved clinical profiles, the molecular structure of each of the latter compounds has been analyzed in solution. |
MPACT Scores for Allen Bennett CornettA = 0 Advisors and Advisees Graph |