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Dissertation Information for Vladimir Arkadievich Azov

NAME:
- Vladimir Arkadievich Azov

DEGREE:
- Ph.D.

DISCIPLINE:
- Chemistry

SCHOOL:
- Emory University (USA) (2001)

ADVISORS:
- Fred M. Menger

COMMITTEE MEMBERS:
- Albert Padwa
- David Goldsmith

MPACT Status: Fully Complete

Title: I. Reactions within and between bilayer membranes. II. Synthesis and properties of water-soluble molecular asterisks

Abstract: "Reactions between a nucleophile (hydroxamate) and an electrophile (an ester) were examined kinetically in solution and when one or both of the reagents were incorporated into vesicles (liposomes). Several modes of reactivity under comparable conditions have rates of decreasing magnitude according to intra-vesicular > solution/solution > solution/vesicle > inter-vesicular. The first and last categories of bond-forming reactions seem to have been investigated kinetically for the first time. Reactivity on a membrane surface depends markedly upon the affinity of the relevant functionalities for the aqueous medium. In the case at hand, one functionality (the hydroxamate) is fully exposed, whereas the other (the ester) is not, a situation that leads to a slow but observable vesicle/vesicle reaction. Vesicle/vesicle reactivity models numerous cell/cell reactions found in biology.

A family of new asterisk-shaped amphiphiles was prepared and studied bye means of tensiometry, calorimetry, dynamic light scattering, UV/Vis spectroscopy, fluorescent spectroscopy, conventional NMR spectroscopy and FIF-PGSE NMR spectroscopy. Mixtures of water-soluble asterisks with cationic surfactants displayed significant synergistic effects; two of asterisks displayed an ability to solubilize highly hydrophobic organic compound (mesitylene). Solid state properties of several derivatives were investigated by means of electron microscopy and X-ray crystallography. These water-soluble molecular asterisks belong to a fast-growing family of structurally novel amphiphiles that are appearing on the scientific scene and expanding the scope of colloid chemistry."

MPACT Scores for Vladimir Arkadievich Azov

A = 0
C = 0
A+C = 0
T = 0
G = 0
W = 0
TD = 0
TA = 0
calculated 2008-04-07 08:00:01

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