Dissertation Information for J. Lucas ZuccarelloNAME:
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SCHOOL: ADVISORS: COMMITTEE MEMBERS: MPACT Status: Fully Complete Title: A highly convergent approach to brevetoxin A Abstract: Through optimized, scaled-up routes to the G and J rings of brevetoxin A, a convergent strategy based upon a Horner-Wadsworth-Emmons coupling reaction completed the GHIJ fragment. Further studies toward an alternative protecting group strategy for the GHIJ fragment elucidated a shortened synthesis. The union of a GHIJ fragment aldehyde with a BCDE fragment phosphine oxide was accomplished using a Horner-Wittig reaction, and the resulting compound was taken on to the decacyclic core through a dithioketal cyclization/reductive etherification sequence. The advanced intermediate thus obtained is expected to be a viable precursor to brevetoxin A. |
MPACT Scores for J. Lucas ZuccarelloA = 0 Advisors and Advisees Graph |