Dissertation Information for Laura Renee SerbusNAME:
DEGREE:
DISCIPLINE:
SCHOOL: ADVISORS: COMMITTEE MEMBERS: MPACT Status: Incomplete - Not_Inspected Title: Functions of kinesin-1 in early development of Drosophila melanogaster Abstract: Complex organisms face an interesting problem in development--starting as a single cell, they must establish asymmetries that will ultimately determine the body plan of the adult, i.e. the anterior/posterior and dorsal/ventral axes. In Drosophila melanogaster , a paradigm system for axis determination, the body axes are established in the developing egg, setting the stage for asymmetries in the rest of development. This patterning relies upon asymmetrical distribution of molecules known as polarity determinants. These determinants have been identified as the proteins Bicoid, Oskar, and Gurken. Asymmetric localization of these factors is accomplished via concentration of their corresponding messenger RNAs in discrete oocyte regions. For example, mRNA for the anterior determinant Bicoid, concentrates at the oocyte anterior, while mRNA for the posterior determinant, Oskar, concentrates at the posterior pole, and mRNA for the D/V determinant, Gurken, concentrates at the anterior-dorsal region. |
MPACT Scores for Laura Renee SerbusA = 0 Advisors and Advisees Graph |