###### ###### ### #### #### ###### ####### ## ## ## ## ## ## ## ## ## # ## # ## # ## ## ## ## ## ## ### ## ## ## # ##### ##### ## ## ### ## ## #### ## ## ## ## ## ### ## ## ## # ## ## ## ## ## ## ## ## ## ## # #### ### ## ### #### #### #### ####### Release : 12.2 of February 1995 The patterns section of PROSITE is developed by: Amos Bairoch Medical Biochemistry Department CMU University of Geneva 1, Rue Michel Servet, 1211 Geneva 4 Switzerland Email : bairoch@cmu.unige.ch Telephone: (+41 22) 784 40 82 The profiles/matrices section of PROSITE is developed by: Philipp Bucher and Kay Oliver Hofmann Biocomputing ISREC Institut Suisse de Recherches Experimentales sur le Cancer 155 ch. des Boveresses, 1066 Epalinges s/Lausanne Switzerland Email : pbucher@isrec-sun1.unil.ch and khofmann@isrec-sun1.unil.ch Telephone: (+41 21) 624 99 43 ---------------------------------------------------------------------------- ---------------------------------------------------------------------------- Document name: PROSITE.LIS Content : LIST OF DOCUMENTATION ENTRIES ---------------------------------------------------------------------------- ---------------------------------------------------------------------------- This release of PROSITE contains 785 documentation entries that describe 1029 different patterns, rules and profiles/matrices. - The character in the first column is used to indicate if a documentation entry is new in this release '+', or has been modified '*' since the last major release (release 11.0 of October 1993). - The numerical characters in positions 3 to 7 provide the documentation entry accession number. - The numerical character in position 9 is used to indicate how many data entries (patterns, rules and profiles/matrices) are described by a documentation entry. Example: * 00374 2 Ets-domain signatures This documentation entry has been updated since the last release ('*'), its accession number is PDOC00374 and it describes two patterns. ----------------------------------------------------------------------------- Post-translational modifications 00001 1 N-glycosylation site 00002 1 Glycosaminoglycan attachment site 00003 1 Tyrosine sulfatation site 00004 1 cAMP- and cGMP-dependent protein kinase phosphorylation site 00005 1 Protein kinase C phosphorylation site 00006 1 Casein kinase II phosphorylation site 00007 1 Tyrosine kinase phosphorylation site 00008 1 N-myristoylation site 00009 1 Amidation site 00010 1 Aspartic acid and asparagine hydroxylation site 00011 1 Vitamin K-dependent carboxylation domain * 00012 1 Phosphopantetheine attachment site * 00013 1 Prokaryotic membrane lipoprotein lipid attachment site * 00342 1 Prokaryotic N-terminal methylation site * 00266 1 Prenyl group binding site (CAAX box) * 00687 1 Protein splicing signature Domains * 00014 1 Endoplasmic reticulum targeting sequence * 00299 1 Microbodies C-terminal targeting signal * 00373 1 Gram-positive cocci surface proteins 'anchoring' hexapeptide 00015 1 Bipartite nuclear targeting sequence 00016 1 Cell attachment sequence * 00017 1 ATP/GTP-binding site motif A (P-loop) 00691 2 Cyclic nucleotide-binding domain signatures * 00018 1 EF-hand calcium-binding domain * 00019 2 Actinin-type actin-binding domain signatures 00297 1 Cofilin/tropomyosin-type actin-binding domain 00376 1 Apple domain 00566 2 Band 4.1 family domain signatures * 00020 1 Kringle domain signature * 00021 1 EGF-like domain cysteine pattern signature 00445 1 Fibrinogen beta and gamma chains C-terminal domain signature * 00022 1 Type II fibronectin collagen-binding domain 00023 1 Hemopexin domain signature * 00537 1 C-type lectin domain signature * 00535 2 Osteonectin domain signatures 00453 1 Somatomedin B domain signature 00377 1 Thyroglobulin type-1 repeat signature 00024 1 'Trefoil' domain signature * 00485 1 Cellulose-binding domain, bacterial type 00486 1 Cellulose-binding domain, fungal type 00025 1 Chitin recognition or binding domain signature 00619 2 Barwin domain signatures 00026 1 WAP-type 'four-disulfide core' domain signature * 00379 1 Phorbol esters / diacylglycerol binding domain 00380 1 C2 domain signature * 00660 1 CAP-Gly domain signature + 00756 1 Ly-6 / u-PAR domain signature * 00604 1 MAM domain signature 00577 1 ZP domain signature DNA or RNA associated proteins 00027 1 'Homeobox' domain signature * 00032 1 'Homeobox' antennapedia-type protein signature 00033 1 'Homeobox' engrailed-type protein signature 00034 1 'Paired box' domain signature * 00035 2 'POU' domain signatures * 00028 1 Zinc finger, C2H2 type, domain * 00449 1 Zinc finger, C3HC4 type, signature * 00031 1 Nuclear hormones receptors DNA-binding region signature 00300 1 GATA-type zinc finger domain * 00360 1 Poly(ADP-ribose) polymerase zinc finger domain * 00378 1 Fungal Zn(2)-Cys(6) binuclear cluster domain 00029 1 Leucine zipper pattern 00036 1 Fos/jun DNA-binding basic domain signature * 00037 2 Myb DNA-binding domain repeat signatures * 00038 1 Myc-type, 'helix-loop-helix' putative DNA-binding domain signature 00301 1 p53 tumor antigen signature * 00578 2 CBF/NF-Y subunits signatures * 00304 1 'Cold-shock' DNA-binding domain signature 00361 1 CTF/NF-I signature * 00374 2 Ets-domain signatures * 00564 2 Fork head domain signatures * 00381 1 HSF-type DNA-binding domain signature 00522 1 IRF family signature * 00382 1 LIM domain signature * 00302 1 SRF-type transcription factors DNA-binding and dimerization domain 00479 1 TEA domain signature 00624 1 Transcription factor TFIIB repeat signature * 00303 1 Transcription factor TFIID repeat signature 00383 1 TFIIS zinc ribbon domain signature 00651 2 Prokaryotic transcription elongation factors signatures * 00039 2 DEAD and DEAH box families ATP-dependent helicases signatures 00030 1 Eukaryotic putative RNA-binding region RNP-1 signature * 00489 1 Fibrillarin signature * 00662 1 MCM2/3/5 family signature 00611 2 XPAC protein signatures * 00658 2 XPGC protein signatures * 00040 1 Bacterial regulatory proteins, araC family signature 00661 1 Bacterial regulatory proteins, arsR family signature 00520 1 Bacterial regulatory proteins, asnC family signature * 00041 1 Bacterial regulatory proteins, crp family signature * 00696 1 Bacterial regulatory proteins, deoR family signature * 00042 1 Bacterial regulatory proteins, gntR family signature * 00366 1 Bacterial regulatory proteins, lacI family signature * 00542 1 Bacterial regulatory proteins, luxR family signature * 00043 1 Bacterial regulatory proteins, lysR family signature * 00477 1 Bacterial regulatory proteins, merR family signature * 00562 1 Transcriptional antiterminators bglG family signature * 00593 2 Sigma-54 factors family signatures * 00592 2 Sigma-70 factors family signatures * 00579 3 Sigma-54 interaction domain signatures 00602 2 Single-strand binding protein family signatures * 00044 1 Bacterial histone-like DNA-binding proteins signature 00645 2 Dps protein family signatures * 00045 1 Histone H2A signature * 00308 1 Histone H2B signature * 00287 2 Histone H3 signatures * 00046 1 Histone H4 signature 00305 1 HMG1/2 signature 00306 1 HMG-I and HMG-Y DNA-binding domain (A T-hook) 00307 1 HMG14 and HMG17 signature * 00550 1 Bromodomain 00517 1 Chromo domain 00544 2 Regulator of chromosome condensation (RCC1) signatures * 00047 1 Protamine P1 signature 00467 1 Nuclear transition protein 1 signature + 00749 2 Nuclear transition protein 2 signatures * 00384 1 Ribosomal protein L2 signature * 00385 1 Ribosomal protein L3 signature * 00309 1 Ribosomal protein L5 signature * 00454 2 Ribosomal protein L6 signatures * 00560 1 Ribosomal protein L9 signature * 00310 1 Ribosomal protein L11 signature * 00625 1 Ribosomal protein L13 signature * 00048 1 Ribosomal protein L14 signature * 00386 1 Ribosomal protein L15 signature * 00506 2 Ribosomal protein L16 signatures + 00778 1 Ribosomal protein L19 signature + 00722 1 Ribosomal protein L20 signature * 00387 1 Ribosomal protein L22 signature * 00049 1 Ribosomal protein L23 signature * 00652 1 Ribosomal protein L27 signature * 00501 1 Ribosomal protein L29 signature * 00551 1 Ribosomal protein L30 signature * 00503 1 Ribosomal protein L33 signature 00626 1 Ribosomal protein L34 signature + 00721 1 Ribosomal protein L35 signature * 00650 1 Ribosomal protein L36 signature + 00724 1 Ribosomal protein L1e signature * 00455 1 Ribosomal protein L19e signature * 00588 2 Ribosomal protein L30e signatures * 00502 1 Ribosomal protein L32e signature 00050 1 Ribosomal protein L46e signature + 00744 2 Ribosomal protein S2 signatures * 00474 2 Ribosomal protein S3 signatures * 00549 1 Ribosomal protein S4 signature * 00505 1 Ribosomal protein S5 signature * 00051 1 Ribosomal protein S7 signature * 00052 1 Ribosomal protein S8 signature * 00311 1 Ribosomal protein S9 signature * 00312 1 Ribosomal protein S10 signature * 00053 1 Ribosomal protein S11 signature * 00054 1 Ribosomal protein S12 signature * 00556 1 Ribosomal protein S13 signature * 00456 1 Ribosomal protein S14 signature * 00313 1 Ribosomal protein S15 signature * 00600 1 Ribosomal protein S16 signature * 00055 1 Ribosomal protein S17 signature * 00056 1 Ribosomal protein S18 signature * 00288 1 Ribosomal protein S19 signature 00457 1 Ribosomal protein S4e signature * 00500 1 Ribosomal protein S6e signature + 00730 1 Ribosomal protein S7e signature 00590 1 Ribosomal protein S17e signature 00546 1 Ribosomal protein S19e signature + 00764 1 Ribosomal protein S21e signature 00458 1 Ribosomal protein S24e signature 00601 1 Ribosomal protein S26e signature + 00743 1 Ribosomal protein S28e signature 00057 1 DNA mismatch repair proteins mutL / hexB / PMS1 signature 00388 1 DNA mismatch repair proteins mutS family signature * 00695 1 mutT domain signature + 00771 1 DnaA protein signature * 00539 2 RecF protein signatures 00276 2 Small, acid-soluble spore proteins, alpha/beta type, signatures Enzymes Oxidoreductases 00058 1 Zinc-containing alcohol dehydrogenases signature * 00059 2 Iron-containing alcohol dehydrogenases signatures * 00060 1 Short-chain alcohol dehydrogenase family signature * 00061 3 Aldo/keto reductase family signatures + 00740 1 NAD-dependent glycerol-3-phosphate dehydrogenase signature + 00753 2 FAD-dependent glycerol-3-phosphate dehydrogenase signatures + 00751 1 Mannitol dehydrogenases signature 00534 1 Histidinol dehydrogenase active site 00062 1 L-lactate dehydrogenase active site * 00063 3 D-isomer specific 2-hydroxyacid dehydrogenases signatures 00697 1 3-hydroxyisobutyrate dehydrogenase signature 00064 2 Hydroxymethylglutaryl-coenzyme A reductases signatures 00065 1 3-hydroxyacyl-CoA dehydrogenase signature 00066 1 Malate dehydrogenase active site signature * 00294 1 Malic enzymes signature 00389 1 Isocitrate and isopropylmalate dehydrogenases signature 00390 1 6-phosphogluconate dehydrogenase signature 00067 1 Glucose-6-phosphate dehydrogenase active site 00391 1 IMP dehydrogenase / GMP reductase signature 00375 2 Bacterial quinoprotein dehydrogenases signatures 00482 1 FMN-dependent alpha-hydroxy acid dehydrogenases active site 00543 2 GMC oxidoreductases signatures * 00484 1 Eukaryotic molybdopterin oxidoreductases signature * 00392 3 Prokaryotic molybdopterin oxidoreductases signatures * 00068 2 Aldehyde dehydrogenases active sites * 00069 1 Glyceraldehyde 3-phosphate dehydrogenase active site 00708 2 Dihydroorotate dehydrogenase signatures + 00783 1 Coproporphyrinogen III oxidase signature 00393 1 Fumarate reductase / succinate dehydrogenase FAD-binding site * 00070 2 Acyl-CoA dehydrogenases signatures 00654 2 Alanine dehydrogenase and pyridine nucleotide transhydrogenase signatures 00071 1 Glutamate / Leucine / Phenylalanine dehydrogenases active site 00573 1 D-amino acid oxidases signature 00716 1 Lysyl oxidase putative copper-binding region signature 00451 1 Delta 1-pyrroline-5-carboxylate reductase signature 00072 1 Dihydrofolate reductase signature 00616 2 Tetrahydrofolate dehydrogenase/cyclohydrolase signatures 00674 1 6-hydroxy-D-nicotine oxidase and reticuline oxidase FAD-binding site 00073 1 Pyridine nucleotide-disulphide oxidoreductases class-I active site 00496 1 Pyridine nucleotide-disulphide oxidoreductases class-II active site * 00570 2 Respiratory-chain NADH dehydrogenase subunit 1 signatures 00468 1 Respiratory-chain NADH dehydrogenase 30 Kd subunit signature * 00521 1 Respiratory-chain NADH dehydrogenase 49 Kd subunit signature * 00555 2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signatures * 00554 3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signatures 00314 1 Nitrite reductases and sulfite reductase putative siroheme-binding sites 00315 1 Uricase signature * 00074 1 Cytochrome c oxidase subunit I, copper B binding region signature 00075 1 Cytochrome c oxidase subunit II, copper A binding region signature 00663 1 Cytochrome c oxidase subunit Vb, zinc binding region signature 00076 2 Multicopper oxidases signatures 00394 2 Peroxidases signatures 00395 2 Catalase signatures * 00396 2 Glutathione peroxidases signatures * 00077 2 Lipoxygenases iron-binding region signatures 00078 1 Extradiol ring-cleavage dioxygenases signature 00079 1 Intradiol ring-cleavage dioxygenases signature 00684 2 Indoleamine 2,3-dioxygenase signatures 00493 1 Bacterial ring hydroxylating dioxygenases alpha-subunit signature * 00397 1 Bacterial luciferase subunits signature 00316 1 Biopterin-dependent aromatic amino acid hydroxylases signature 00080 2 Copper type II, ascorbate-dependent monooxygenases signatures * 00398 2 Tyrosinase signatures 00399 2 Fatty acid desaturases signatures 00081 1 Cytochrome P450 cysteine heme-iron ligand signature 00512 1 Heme oxygenase signature 00082 2 Copper/Zinc superoxide dismutase signatures 00083 1 Manganese and iron superoxide dismutases signature 00084 1 Ribonucleotide reductase large subunit signature 00317 1 Ribonucleotide reductase small subunit signature 00085 2 Nitrogenases component 1 alpha and beta subunits signatures 00580 2 NifH/frxC family signatures 00400 2 Nickel-dependent hydrogenases large subunit signatures 00608 1 Glutamyl-tRNA reductase signature + 00755 1 Bacterial-type phytoene dehydrogenase signature 00665 1 Glycine radical signature + 00780 2 Ergosterol biosynthesis ERG4/ERG24 family signatures Transferases 00086 1 Thymidylate synthase active site 00320 1 Methylated-DNA--protein-cysteine methyltransferase active site * 00087 1 N-6 Adenine-specific DNA methylases signature * 00088 1 N-4 cytosine-specific DNA methylases signature * 00089 2 C-5 cytosine-specific DNA methylases signatures * 00656 2 Uroporphyrin-III C-methyltransferase signatures * 00090 1 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site 00319 1 Phosphoribosylglycinamide formyltransferase active site 00091 1 Aspartate and ornithine carbamoyltransferases signature 00635 2 Transketolase signatures + 00741 1 Transaldolase active site * 00402 2 Acyltransferases ChoActase / COT / CPT family signatures * 00092 3 Thiolases signatures 00093 1 Chloramphenicol acetyltransferase active site * 00094 1 Bacterial hexapeptide-repeat containing-transferases signature * 00529 1 Beta-ketoacyl synthases active site 00403 1 Chalcone and stilbene synthases active site + 00752 2 Myristoyl-CoA:protein N-myristoyltransferase signatures * 00404 1 Gamma-glutamyltranspeptidase signature 00473 1 Transglutaminases active site 00095 1 Phosphorylase pyridoxal-phosphate attachment site * 00359 1 UDP-glucoronosyl and UDP-glucosyl transferases signature * 00096 1 Purine/pyrimidine phosphoribosyl transferases signature * 00405 1 Glutamine amidotransferases class-I active site 00406 1 Glutamine amidotransferases class-II active site 00557 1 Thymidine phosphorylase signature * 00369 2 S-adenosylmethionine synthetase signatures 00407 2 Polyprenyl synthetases signatures * 00703 1 Protein prenyltransferases alpha subunit repeat signature 00581 1 Riboflavin synthase alpha chain family Lum-binding site signature 00630 2 Dihydropteroate synthase signatures * 00097 2 EPSP synthase signatures * 00098 1 Aminotransferases class-I pyridoxal-phosphate attachment site 00518 1 Aminotransferases class-II pyridoxal-phosphate attachment site * 00519 1 Aminotransferases class-III pyridoxal-phosphate attachment site 00618 1 Aminotransferases class-IV signature * 00514 1 Aminotransferases class-V pyridoxal-phosphate attachment site 00370 1 Hexokinases signature 00099 1 Galactokinase signature 00545 1 GHMP kinases putative ATP-binding domain 00336 1 Phosphofructokinase signature * 00504 2 pfkB family of carbohydrate kinases signatures 00490 1 Phosphoribulokinase signature 00524 1 Thymidine kinase cellular-type signature 00408 2 FGGY family of carbohydrate kinases signatures * 00100 3 Protein kinases signatures 00101 1 Pyruvate kinase active site signature * 00710 2 Phosphatidylinositol 3- and 4-kinases signatures 00102 1 Phosphoglycerate kinase signature * 00289 1 Aspartokinase signature 00701 1 Glutamate 5-kinase signature 00103 1 ATP:guanido phosphotransferases active site * 00318 2 PTS HPr component phosphorylation sites signatures * 00528 2 PTS EIIA domains phosphorylation sites signatures + 00795 1 PTS EIIB domains cysteine phosphorylation site signature 00104 1 Adenylate kinase signature * 00409 1 Nucleoside diphosphate kinases active site 00670 1 Guanylate kinase signature 00105 1 Phosphoribosyl pyrophosphate synthetase signature 00631 1 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature * 00410 2 Bacteriophage-type RNA polymerase family active site signatures 00106 1 Eukaryotic RNA polymerase II heptapeptide repeat + 00790 1 Eukaryotic RNA polymerases 15 Kd subunits signature * 00411 1 Eukaryotic RNA polymerases 30 to 40 Kd subunits signature * 00412 1 DNA polymerase family A signature * 00107 1 DNA polymerase family B signature * 00452 1 DNA polymerase family X signature 00108 1 Galactose-1-phosphate uridyl transferase active site signature 00638 3 ADP-glucose pyrophosphorylase signatures 00653 2 2'-5'-oligoadenylate synthetases signatures 00321 1 CDP-alcohol phosphatidyltransferases signature * 00527 2 PEP-utilizing enzymes signatures 00322 2 Rhodanese signatures Hydrolases * 00109 2 Phospholipase A2 active sites signatures 00110 1 Lipases, serine active site * 00111 1 Colipase signature * 00112 2 Carboxylesterases type-B signatures 00413 2 Pectinesterase signatures * 00113 1 Alkaline phosphatase active site * 00538 2 Histidine acid phosphatases signatures 00627 2 5'-nucleotidase signatures * 00114 1 Fructose-1-6-bisphosphatase active site 00115 1 Serine/threonine specific protein phosphatases signature + 00785 2 Protein phosphatase 2A regulatory subunit PR55 signatures + 00792 1 Protein phosphatase 2C signature * 00323 1 Tyrosine specific protein phosphatases active site 00547 2 Inositol monophosphatase family signatures * 00357 1 Prokaryotic zinc-dependent phospholipase C signature 00116 1 3'5'-cyclic nucleotide phosphodiesterases signature * 00530 1 cAMP phosphodiesterases class-II signature * 00117 2 Sulfatases signatures 00598 3 AP endonucleases family 1 signatures * 00599 3 AP endonucleases family 2 signatures * 00711 2 Deoxyribonuclease I signatures 00615 1 Endonuclease III iron-sulfur binding region signature 00448 1 Ribonuclease III family signature 00558 1 Bacterial Ribonuclease P protein component signature 00459 2 Ribonuclease T2 family histidine active sites 00118 1 Pancreatic ribonuclease family signature * 00414 2 Beta-amylase active sites 00646 1 Glucoamylase active site region signature * 00415 1 Polygalacturonase active site * 00416 1 Clostridium cellulosome enzymes repeated domain signature * 00620 2 Chitinases class I signatures 00119 1 Alpha-lactalbumin / lysozyme C signature 00443 1 Alpha-galactosidase signature 00717 2 Trehalase signatures 00324 1 Alpha-L-fucosidase putative active site 00495 2 Glycosyl hydrolases family 1 signatures 00531 2 Glycosyl hydrolases family 2 signatures * 00621 1 Glycosyl hydrolases family 3 active site * 00565 1 Glycosyl hydrolases family 5 signature * 00563 2 Glycosyl hydrolases family 6 signatures 00640 1 Glycosyl hydrolases family 8 signature * 00511 2 Glycosyl hydrolases family 9 active sites signatures * 00510 1 Glycosyl hydrolases family 10 active site * 00622 2 Glycosyl hydrolases family 11 active site signatures + 00794 1 Glycosyl hydrolases family 16 signature 00507 1 Glycosyl hydrolases family 17 signature + 00737 1 Glycosyl hydrolases family 25 active sites signature 00120 2 Glycosyl hydrolases family 31 signatures 00532 1 Glycosyl hydrolases family 32 active site + 00787 1 Glycosyl hydrolases family 39 putative active site * 00713 1 Prokaryotic transglycosylases signature 00447 1 Alkylbase DNA glycosidases alkA family signature 00121 1 Uracil-DNA glycosylase signature * 00603 2 S-adenosyl-L-homocysteine hydrolase signatures 00548 1 Cytosol aminopeptidase signature 00417 1 Aminopeptidase P and proline dipeptidase signature 00575 1 Methionine aminopeptidase signature 00678 1 Renal dipeptidase active site * 00122 2 Serine carboxypeptidases, active sites * 00123 2 Zinc carboxypeptidases, zinc-binding regions signatures * 00124 2 Serine proteases, trypsin family, active sites * 00125 3 Serine proteases, subtilase family, active sites 00571 2 Serine proteases, V8 family, active sites * 00657 2 Serine proteases, omptin family signatures * 00587 1 Prolyl oligopeptidase family serine active site * 00358 2 ClpP proteases active sites * 00126 3 Eukaryotic thiol (cysteine) proteases active sites * 00127 1 Ubiquitin carboxyl-terminal hydrolases family 1 putative active- site + 00750 2 Ubiquitin carboxyl-terminal hydrolases family 2 signatures * 00128 1 Eukaryotic and viral aspartyl proteases active site * 00129 1 Neutral zinc metallopeptidases, zinc-binding region signature * 00472 1 Matrixins cysteine switch * 00130 1 Insulinase family, zinc-binding region signature + 00779 1 Glycoprotease family signature * 00131 1 recA signature * 00326 1 Proteasome A-type subunits signature 00668 1 Proteasome B-type subunits signature * 00418 3 Signal peptidases I signatures 00669 1 Signal peptidases II signature 00494 1 Amidases signature 00132 2 Asparaginase / glutaminase active sites signatures 00133 1 Urease active site * 00613 2 ArgE / dapE / ACY1 / CPG2 / yscS family signatures 00401 2 Dihydroorotase signatures * 00134 3 Beta-lactamases classes -A, -C, and -D active site 00606 2 Beta-lactamases class B signatures 00135 2 Arginase and agmatinase signatures 00419 1 Adenosine and AMP deaminase signature * 00702 1 Cytidine & deoxycytidylate deaminases zinc-binding region signature 00672 2 GTP cyclohydrolase I signatures 00712 2 Nitrilases / cyanide hydratase signatures * 00325 1 Inorganic pyrophosphatase signature * 00136 2 Acylphosphatase signatures * 00137 1 ATP synthase alpha and beta subunits signature * 00138 1 ATP synthase gamma subunit signature * 00327 1 ATP synthase delta (OSCP) subunit signature 00420 1 ATP synthase a subunit signature 00526 1 ATP synthase c subunit signature * 00139 1 E1-E2 ATPases phosphorylation site * 00328 2 Sodium and potassium ATPases beta subunits signatures 00140 2 Cutinase active sites signatures Lyases * 00329 1 DDC / GAD / HDC pyridoxal-phosphate attachment site 00585 1 Orn/Lys/Arg decarboxylases family 1 pyridoxal-phosphate attachment site 00685 2 Orn/DAP/Arg decarboxylases family 2 signatures 00141 1 Orotidine 5'-phosphate decarboxylase active site 00330 2 Phosphoenolpyruvate carboxylase active sites 00421 1 Phosphoenolpyruvate carboxykinase (GTP) signature 00460 1 Phosphoenolpyruvate carboxykinase (ATP) signature 00705 2 Uroporphyrinogen decarboxylase signatures * 00536 1 Indole-3-glycerol phosphate synthase signature 00142 1 Ribulose bisphosphate carboxylase large chain active site 00143 1 Fructose-bisphosphate aldolase class-I active site * 00523 2 Fructose-bisphosphate aldolase class-II signatures 00441 1 Malate synthase signature * 00422 1 Citrate synthase signature 00643 2 Alpha-isopropylmalate and homocitrate synthases signatures 00144 2 KDPG and KHG aldolases active site signatures 00145 1 Isocitrate lyase signature 00667 1 Beta-eliminating lyases pyridoxal-phosphate attachment site * 00331 2 DNA photolyases signatures * 00146 1 Eukaryotic-type carbonic anhydrases signature * 00586 2 Prokaryotic-type carbonic anhydrases signatures 00147 1 Fumarate lyases signature 00423 1 Aconitase family signature 00690 2 Dihydroxy-acid and 6-phosphogluconate dehydratases signatures + 00788 1 Dehydroquinase class I active site + 00789 1 Dehydroquinase class II signature 00148 1 Enolase signature * 00149 1 Serine/threonine dehydratases pyridoxal-phosphate attachment site * 00150 1 Enoyl-CoA hydratase/isomerase signature + 00738 2 Imidazoleglycerol-phosphate dehydratase signatures 00151 1 Tryptophan synthase alpha chain signature 00152 1 Tryptophan synthase beta chain pyridoxal-phosphate attachment site 00153 1 Delta-aminolevulinic acid dehydratase active site 00671 2 Prephenate dehydratase signatures 00569 2 Dihydrodipicolinate synthetase signatures + 00700 1 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site 00424 1 Phenylalanine and histidine ammonia-lyases signature * 00461 1 Porphobilinogen deaminase cofactor-binding site 00677 1 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site + 00720 2 Glyoxalase I signatures 00647 2 Cytochrome c and c1 heme lyases signatures 00425 1 Guanylate cyclases signature 00628 3 Chorismate synthase signatures + 00759 2 6-pyruvoyl tetrahydropterin synthase signatures 00462 1 Ferrochelatase signature Isomerases 00332 1 Alanine racemase pyridoxal-phosphate attachment site * 00714 2 Aspartate and glutamate racemases signatures 00706 2 Mandelate racemase / muconate lactonizing enzyme family signatures 00471 1 Aldose 1-epimerase putative active site * 00154 1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature * 00426 2 FKBP-type peptidyl-prolyl cis-trans isomerase signatures * 00155 1 Triosephosphate isomerase active site 00156 2 Xylose isomerase signatures + 00746 2 Phosphomannose isomerase type I signatures 00157 2 Phosphoglucose isomerase signatures * 00158 1 Phosphoglycerate mutase family phosphohistidine signature * 00589 1 Phosphoglucomutase and phosphomannomutase phosphoserine signature * 00470 1 Methylmalonyl-CoA mutase signature 00159 1 Eukaryotic DNA topoisomerase I active site 00333 1 Prokaryotic DNA topoisomerase I active site 00160 1 DNA topoisomerase II signature Ligases * 00161 1 Aminoacyl-transfer RNA synthetases class-I signature * 00363 2 Aminoacyl-transfer RNA synthetases class-II signatures * 00614 1 WHEP-TRS domain signature 00335 1 ATP-citrate lyase and succinyl-CoA ligases active site * 00162 3 Glutamine synthetase signatures * 00659 2 D-alanine--D-alanine ligase signatures + 00773 2 Folylpolyglutamate synthase signatures 00463 2 Ubiquitin-activating enzyme signatures * 00163 1 Ubiquitin-conjugating enzymes active site 00595 2 Formate--tetrahydrofolate ligase signatures 00444 1 Adenylosuccinate synthetase active site 00488 2 Argininosuccinate synthase signatures 00164 1 Phosphoribosylglycinamide synthetase signature 00676 2 Carbamoyl-phosphate synthase subdomain signatures 00295 2 ATP-dependent DNA ligase signatures Others 00165 2 Isopenicillin N synthetase signatures * 00334 2 Site-specific recombinases signatures + 00770 1 Transposases, Mutator family, signature + 00731 1 OHHL biosynthesis luxI family signature * 00166 1 Thiamine pyrophosphate enzymes signature * 00167 1 Biotin-requiring enzymes attachment site * 00168 1 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site 00427 1 Putative AMP-binding domain signature Electron transport proteins 00169 1 Cytochrome c family heme-binding site signature * 00170 1 Cytochrome b5 family, heme-binding domain signature * 00171 2 Cytochrome b/b6 signatures 00464 1 Cytochrome b559 subunits heme-binding site signature 00688 2 Nickel-dependent hydrogenases b-type cytochrome subunit signatures + 00767 2 Succinate dehydrogenase cytochrome b subunit signatures * 00172 1 Thioredoxin family active site 00173 1 Glutaredoxin active site * 00174 1 Type-1 copper (blue) proteins signature * 00175 1 2Fe-2S ferredoxins, iron-sulfur binding region signature * 00642 1 Adrenodoxin family, iron-sulfur binding region signature 00176 1 4Fe-4S ferredoxins, iron-sulfur binding region signature 00515 1 High potential iron-sulfur proteins signature 00177 2 Rieske iron-sulfur protein signatures 00178 1 Flavodoxin signature 00179 1 Rubredoxin signature 00583 1 Electron transfer flavoprotein alpha-subunit signature Other transport proteins 00180 1 Class I metallothioneins signature 00181 2 Ferritin iron-binding regions signatures 00475 1 Bacterioferritin signature 00182 3 Transferrins signatures + 00793 1 Globins profile 00183 1 Plant hemoglobins signature 00476 1 Hemerythrins signature 00184 2 Arthropod hemocyanins / insect LSPs signatures * 00185 1 ABC transporters family signature * 00364 1 Binding-protein-dependent transport systems inner membrane component signature 00692 1 ABC-2 type transport system integral membrane proteins signature * 00186 1 Serum albumin family signature 00617 2 Transthyretin signatures 00499 1 Avidin / Streptavidin family signature 00428 1 Eukaryotic cobalamin-binding proteins signature * 00187 1 Lipocalin signature * 00188 1 Cytosolic fatty-acid binding proteins signature 00686 1 Acyl-CoA-binding protein signature 00367 1 LBP / BPI / CETP family signature 00516 1 Plant lipid transfer proteins signature 00338 2 Uteroglobin family signatures * 00189 1 Mitochondrial energy transfer proteins signature * 00190 2 Sugar transport proteins signatures 00698 2 LacY family proton/sugar symporters signatures + 00784 2 PTR2 family proton/oligopeptide symporters signatures 00681 1 Sodium:alanine symporter family signature * 00591 2 Sodium:dicarboxylate symporter family signatures 00680 1 Sodium:galactoside symporter family signature * 00533 2 Sodium:neurotransmitter symporter family signatures 00429 2 Sodium:solute symporter family signatures + 00726 1 glpT family of transporters signature + 00769 2 Bacterial formate and nitrite transporters signatures 00337 2 Prokaryotic sulfate- and thiosulfate-binding proteins signatures * 00191 1 Amino acid permeases signature 00513 1 Aromatic amino acids permeases signature 00192 2 Anion exchangers family signatures * 00193 1 MIP family signature 00498 1 General diffusion gram-negative porins signature 00483 1 Eukaryotic mitochondrial porin signature * 00194 1 Insulin-like growth factor binding proteins signature Structural proteins 00339 1 43 Kd postsynaptic protein signature 00340 2 Actins signatures * 00195 1 Annexins repeated domain signature 00196 2 Clathrin light chains signatures * 00431 2 Clusterin signatures * 00341 2 Connexins signatures 00197 1 Crystallins beta and gamma 'Greek key' motif signature * 00362 1 Dynamin family signature + 00739 1 Fungal hydrophobins signature * 00198 1 Intermediate filaments signature 00632 1 Involucrin signature * 00343 1 Kinesin motor domain signature 00492 1 Myelin basic protein signature 00491 1 Myelin P0 protein signature * 00497 2 Myelin proteolipid protein signatures 00344 2 Neuromodulin (GAP-43) signatures * 00689 1 Osteopontin signature 00719 1 Peripherin / rom-1 signature * 00372 1 Profilin signature 00298 1 Surfactant associated polypeptide SP-C palmitoylation sites 00345 2 Synapsins signatures * 00368 1 Synaptobrevin signature 00525 1 Synaptophysin / synaptoporin signature 00290 1 Tropomyosins signature * 00199 1 Tubulin subunits alpha, beta, and gamma signature 00200 1 Tubulin-beta mRNA autoregulation signal * 00201 1 Tau and MAP proteins tubulin-binding domain signature * 00202 1 Neuraxin and MAP1B proteins repeated region signature 00609 2 F-actin capping protein alpha subunit signatures 00203 1 F-actin capping protein beta subunit signature * 00568 2 Vinculin family signatures * 00204 2 Amyloidogenic glycoprotein signatures * 00205 1 Cadherins extracellular repeated domain signature 00206 1 Insect flexible cuticle proteins signature * 00207 2 Gas vesicles protein GVPa signatures 00208 1 Gas vesicles protein GVPc repeated domain signature * 00508 1 Flagella basal body rod proteins signature 00480 1 Plant viruses icosahedral capsid proteins 'S' region signature 00346 1 Potexviruses and carlaviruses coat protein signature Receptors * 00209 1 Neurotransmitter-gated ion-channels signature * 00210 1 G-protein coupled receptors signature * 00559 2 G-protein coupled receptors family 2 signatures + 00754 3 G-protein coupled receptors family 3 signatures * 00211 1 Visual pigments (opsins) retinal binding site * 00291 2 Bacterial rhodopsins signatures 00212 1 Receptor tyrosine kinase class II signature * 00213 1 Receptor tyrosine kinase class III signature 00629 2 Receptor tyrosine kinase class V signatures * 00214 2 Growth factor and cytokines receptors family signatures * 00561 1 TNFR/NGFR family cysteine-rich region signature * 00215 1 Integrins alpha chain signature 00216 1 Integrins beta chain cysteine-rich domain signature 00430 1 Natriuretic peptides receptors signature * 00217 1 Photosynthetic reaction center proteins signature + 00748 2 Antenna complexes alpha and beta subunits signatures 00347 1 Photosystem I psaA and psaB proteins signature + 00786 1 Photosystem I psaG and psaK proteins signature * 00218 1 Phytochrome chromophore attachment site 00348 1 Speract receptor repeated domain signature * 00354 1 TonB-dependent receptor proteins signature 00371 1 Transmembrane 4 superfamily signature 00465 1 Bacterial chemotaxis sensory transducers signature + 00732 2 ER lumen protein retaining receptor signatures Cytokines and growth factors 00634 1 Granulins signature * 00220 1 HBGF/FGF family signature 00540 2 PTN/MK heparin-binding protein family signatures * 00221 1 Nerve growth factor family signature 00222 1 Platelet-derived growth factor (PDGF) family signature * 00434 2 Small cytokines (intercrine/chemokine) signatures * 00223 1 TGF-beta family signature * 00224 1 TNF family signature 00219 1 Wnt-1 family signature * 00225 1 Interferon alpha and beta family signature 00584 1 Granulocyte-macrophage colony-stimulating factor signature 00226 1 Interleukin-1 signature * 00349 1 Interleukin-2 signature * 00655 1 Interleukins -4 and -13 signature * 00227 1 Interleukin-6 / G-CSF / MGF family signature 00228 1 Interleukin-7 signature 00450 1 Interleukin-10 signature 00509 1 LIF / OSM family signature Hormones and active peptides 00229 1 Adipokinetic hormone family signature 00230 1 Bombesin-like peptides family signature 00231 1 Calcitonin / CGRP / IAPP family signature 00442 1 Corticotropin-releasing factor family signature 00644 1 Erythropoietin signature 00365 2 Granins signatures 00673 1 Galanin signature 00232 1 Gastrin / cholecystokinin family signature 00233 1 Glucagon / GIP / secretin / VIP family signature * 00623 2 Glycoprotein hormones alpha chain signatures * 00234 2 Glycoprotein hormones beta chain signatures 00432 1 Gonadotropin-releasing hormones signature 00235 1 Insulin family signature 00236 1 Natriuretic peptides signature * 00237 1 Neurohypophysial hormones signature + 00747 1 Neuromedin U signature 00238 1 Pancreatic hormone family signature 00296 1 Parathyroid hormone family signature 00466 1 Pyrokinins signature 00239 2 Somatotropin, prolactin and related hormones signatures 00240 1 Tachykinin family signature 00433 1 Thymosin beta-4 family signature + 00757 1 Urotensin II signature * 00241 1 Cecropin family signature 00242 1 Mammalian defensins signature 00356 1 Insect defensins signature + 00729 2 Neutrophil bactenecins signatures * 00243 1 Endothelin family signature Toxins * 00244 1 Plant thionins signature + 00725 1 Gamma-thionins family signature 00245 1 Snake toxins signature 00435 1 Myotoxins signature 00246 1 Heat-stable enterotoxins signature 00247 1 Aerolysin type toxins signature * 00248 1 Shiga/ricin ribosomal inactivating toxins active site signature 00249 1 Channel forming colicins signature 00481 1 Hok/gef family cell toxic proteins signature 00250 2 Staphyloccocal enterotoxins / Streptococcal pyrogenic exotoxins signatures 00436 1 Thiol-activated cytolysins signature * 00251 1 Membrane attack complex components / perforin signature Inhibitors * 00252 1 Pancreatic trypsin inhibitor (Kunitz) family signature * 00253 1 Bowman-Birk serine protease inhibitors family signature * 00254 1 Kazal serine protease inhibitors family signature 00255 1 Soybean trypsin inhibitor (Kunitz) protease inhibitors family signature * 00256 1 Serpins signature * 00257 1 Potato inhibitor I family signature 00258 1 Squash family of serine protease inhibitors signature + 00766 1 Streptomyces subtilisin-type inhibitors signature * 00259 1 Cysteine proteases inhibitors signature 00260 1 Tissue inhibitors of metalloproteinases signature * 00350 1 Cereal trypsin/alpha-amylase inhibitors family signature 00440 1 Alpha-2-macroglobulin family thiolester region signature 00351 1 Disintegrins signature 00478 1 Lambdoid phages regulatory protein CIII signature Protein secretion and chaperones 00268 1 Chaperonins cpn60 signature * 00576 1 Chaperonins cpn10 signature * 00610 3 Chaperonins TCP-1 signatures + 00791 1 Heat shock hsp20 proteins family profile * 00269 3 Heat shock hsp70 proteins family signatures * 00270 1 Heat shock hsp90 proteins family signature * 00679 2 Chaperonins clpA/B signatures * 00553 2 DnaJ domains signatures * 00683 1 Bacterial type II secretion system protein D signature * 00567 1 Bacterial type II secretion system protein E signature * 00682 1 Bacterial type II secretion system protein F signature + 00763 1 Bacterial export FHIPEP family signature 00612 2 Protein secY signatures * 00552 1 Gram-negative pili assembly chaperone signature * 00272 1 SRP54-type proteins GTP-binding domain signature + 00727 1 Cytochrome c oxidase assembly factor COX10/ctaB/cyoE signature + 00728 2 Cyclin-dependent kinases regulatory subunits signatures Others 00261 1 Pentaxin family signature 00262 1 Immunoglobulins and major histocompatibility complex proteins signature 00263 2 Prion protein signatures * 00264 1 Cyclins signature 00265 1 Proliferating cell nuclear antigen signature * 00267 1 Arrestins signature * 00572 1 AAA-protein family signature * 00271 1 Ubiquitin family signature + 00781 1 ADP-ribosylation factors family signature + 00782 1 SAR1 family signature * 00574 1 Beta-transducin family Trp-Asp repeats signature * 00438 1 Ras GTPase-activating proteins signature * 00605 1 Guanine-nucleotide dissociation stimulators CDC24 family signature * 00594 1 Guanine-nucleotide dissociation stimulators CDC25 family signature 00649 2 MARCKS family signatures 00487 1 Stathmin family signature * 00273 1 GTP-binding elongation factors signature * 00648 2 Elongation factor 1 beta/beta'/delta chain signatures 00641 1 Eukaryotic initiation factor 4E signature * 00274 1 Eukaryotic initiation factor 5A hypusine signature + 00723 1 Initiation factor 3 signature * 00607 1 Prokaryotic-type peptide chain release factors signature + 00775 1 Transcription termination factor nusG signature * 00636 3 Calreticulin family signatures 00675 2 Calsequestrin signatures * 00275 1 S-100/ICaBP type calcium binding protein signature 00293 1 Hemolysin-type calcium-binding region signature * 00469 1 HlyD family secretion proteins signature 00439 2 P-II protein signatures 00633 2 14-3-3 proteins signatures + 00742 1 BTG1 family signature + 00765 2 G10 protein signatures * 00704 1 GTP1/OBG family signature * 00694 1 HIT family signature 00277 1 Caseins alpha/beta signature + 00761 2 Clathrin adaptor complexes medium chain signatures + 00760 1 Clathrin adaptor complexes small chain signature 00699 2 Ependymins signatures 00709 1 Epimorphin family signature + 00772 2 Extracellular proteins SCP/Tpx-1/Ag5/PR-1/Sc7 signatures * 00278 2 Legume lectins signatures * 00279 1 Vertebrate galactoside-binding lectin signature * 00280 2 Lysosome-associated membrane glycoproteins signatures 00281 1 Glycophorin A signature + 00774 1 Oxysterol-binding protein family signature * 00718 1 Yeast PIR proteins repeats signature 00282 1 Seminal vesicle protein I repeats signature 00446 1 Seminal vesicle protein II repeats signature + 00762 1 Serum amyloid A proteins signature + 00758 2 Spermadhesins family signatures * 00596 1 Stress-induced proteins SRP1/TIP1 family signature + 00745 1 Syndecans signature 00541 1 Tissue factor signature + 00768 2 Translationally controlled tumor protein signatures 00292 1 HCP repeats signature * 00283 1 Bacterial ice-nucleation proteins octamer repeat 00352 1 Cell cycle proteins ftsW / rodA / spoVE signature * 00582 2 Enterobacterial virulence outer membrane protein signatures 00353 1 Staphylocoagulase repeat signature * 00284 1 11-S plant seed storage proteins signature 00285 2 Dehydrins signatures 00597 1 Germin family signature 00639 1 Oleosins signature * 00355 1 Small hydrophilic plant seed proteins signature * 00437 1 Pathogenesis-related proteins BetvI family signature 00715 1 Pollen proteins Ole e I family signature 00286 1 Thaumatin family signature * 00707 1 Hypothetical YCR59c/yigZ family signature -----PROSITE--release-12.2-----------End-of-file-PROSITE.LIS-----------------