This is the program "Digispeak" for reading in DNA sequences with a Graf-Bar or similar sonic digitizer. The program is (at least not yet) professionally polished, but we have read in well over 100,000 nucleotides using this program with good results. Included are: (1) This Read-Me document, (2) Digi Instructions, for users, (3) Digi Setup, for setting up the digitizer, building a cable, etc., (4) the digitizer menu, Digi menu, as a PICT file which can be opened by any drawing program, and (5) the program Digispeak itself. In case of problems or suggestions, I can be reached as follows: Ned Mantei Department of Biochemistry Swiss Federal Institute of Technology ETH-Zentrum CH-8092 ZŸrich, Switzerland Telephone: (011*) 41-1-256-3050 Fax: (011*) 41-1-252-8744 *code for calling Europe from North America only.