SUBMISSION OF SEQUENCE DATA TO GENBANK		3/94


YOUR MANUSCRIPT

Most journals now expect that DNA and amino acid sequences that 
appear in articles will be submitted to a sequence database 
before publication. Please be aware that it is only necessary to
submit the sequence to one database, whichever one is most convenient,
without regard for where the sequence may be published. Data exchange 
between GenBank, EMBL and DDBJ occurs daily. 


AUTHORIN

The easiest, and preferable, method of formatting your sequence 
data for submission to GenBank is to use the Authorin program.  This 
program is available for IBM or Macintosh computers and can be 
obtained free of charge from:

 Authorin
 National Center for Biotechnology Information
 National Library of Medicine
 Bldg. 38A, Room 8N-803
 Bethesda, MD 20894

 Voice:  (301) 496-2475          
 FAX:  (301) 480-9241

 E-Mail:  authorin@ncbi.nlm.nih.gov

You can also obtain Authorin from the NCBI anonymous ftp server
(ncbi.nlm.nih.gov). Login as anonymous and use your e-mail
address as your password. You will find the Mac version (3.0)
in the /pub/authorin/mac directory and the DOS version (1.2)
in the /pub/authorin/dos directory.

Authorin employs easy-to-use on-screen forms in which to enter 
information about the submitter of the sequence, the associated 
bibliographic and biological data, and the sequence itself. The 
program is provided with full documentation.  Submission files 
generated by Authorin may be sent by electronic mail to:
 
     gb-sub@ncbi.nlm.nih.gov


As an alternative, the submission file can be copied to floppy disk
and mailed to GenBank Submissions at the above postal address. Please
label the disk with your name and file name and indicate whether it is
a PC or Mac disk.


ACCESSION NUMBERS

For each sequence that you submit, a unique identification number will 
be issued by the GenBank staff (within 24 hours, if received via 
electronic mail). This accession number serves as confirmation that you 
have submitted your data, and allows the community to retrieve the data 
upon reading the journal article. 

The accession number should be included in your manuscript, preferably 
in a footnote on the first page of the article, or as individual journal 
procedures direct.




UPDATES

An electronic form is available for providing update information, and 
can be requested from:

      update@ncbi.nlm.nih.gov

If your update information is a simple revision, such as a citation change
or release of information, you can send an e-mail message in paragraph form
explaining the change. Be sure to give the accession number of the sequence
to be updated along with all update, correction, or publication information.
Alternatively, you may send a copy of your GenBank flat file with the updated
information and include a message indicating where changes have been made. 

Authorin may be used for updates as long as you clearly indicate that it
is an update and not a new submission. Also, be sure to indicate the
accession number for the record being updated.


SUBMISSION FORM

We strongly urge submitters to use Authorin, but if you are unable to do so,
we have an electronic submission form that can be used as an alternative.  
Please specify that you need the electronic submission form. Request it from:

      authorin@ncbi.nlm.nih.gov


                     CONFIDENTIALITY 

Many authors are concerned that submission of data prior to appearance 
of a manuscript may compromise their work. GenBank will, upon request, 
withhold release of the submitted data until the appearance of your
manuscript.

***PLEASE NOTE***

It is important that you inform us of acceptance or appearance of the 
data in a publication; please send the full publication data - all 
authors, title, journal, volume, pages and date - to the following
address:

	update@ncbi.nlm.nih.gov