EUFEPSFourth European Congress of

Pharmaceutical Sciences

Milan, Italy, September 11-13, 1998
SISF
Milan

Milan Cathedral

SCIENTIFIC PROGRAMME

The Scientific Programme is summarised below. Invited Plenary and Keynote Lectures will be presented by distinguished international scientists. There will be Symposia, Mini-Symposia, Workshops (featuring invited lectures plus additional oral communications selected from those submitted) and 12 Poster Sessions. Three special Round-Table Discussions will be held, including one on: "Generic Drugs and Intellectual Property Rights in the Global Pharmaceutical Market."

Late-breaking Abstracts
Subject to the availability of space, Abstracts on late-breaking research work will be rapidly considered for poster presentation. Although Late-breaking Abstracts will not be published in the Abstract Book, a copy of these abstracts will be distributed to participants. Please contact the EUFEPS '98 Organizing Secretariat for further details.

Abstract Book
Accepted Abstracts received by the deadline will be published in a supplement of the European Journal of Pharmaceutical Sciences (Elsevier Science), with an official ISSN abstracted by all the major abstracting agencies. This is the Official Journal of the European Federation for Pharmaceutical Sciences. All participants will receive the Abstract Book with the Final Programme at the Congress itself.

New EUFEPS Awards
Details of the new EUFEPS Young Investigator Awards presented in Milan for outstanding research achievements in Poster Presentation can be found below.

The Segre Award in Pharmacokinetics/Pharmacodynamics will be presented for the first time at EUFEPS '98 in Milan. Further details can be found in the General Information section.

Milan

Synopsis of Scientific Programme

Morning, Friday, September 11th.

Plenary Lecture 1

Receptors As Drug Targets

Plenary Lecture 2

Challenges For Drug Delivery

Poster Sessions

1, 2, 3, 4, 5

 

 

Afternoon, Friday, September 11th.

Round Table

Generic Drugs And Intellectual Property Rights In The Global Pharmaceutical Market

Mini-Symposium 1

New Trends In Alzheimer's Disease

Workshop 1

Drug Delivery

Workshop 2

New Targets in Drug Discovery

 

 

Morning, Saturday, September 12th.

Workshop 3

Drug Targeting (Organ Selectivity - Cell Targeting - Cell Signalling)

Mini-Symposium 2

New Perspectives in Analytical Chemistry

Symposium

Drugs and Cancer:
Experimental and Clinical Pharmacology of Tumours and Apoptosis

Symposium

The 5th Framework Programme:
Perspectives and Impact on European Research

Symposium

New Trends in Bioavailability - Bioequivalence Studies

Poster Sessions

6, 7

 

 

Afternoon, Saturday, September 12th.

Workshop 4

Drug Metabolism And Pharmacokinetics

Workshop 5

Chemical Development and Drug Characterization

Mini-Symposium 3

Routes for Site-Specific Delivery

Mini-Symposium 4

Biotechnology Drugs and the Therapeutic Revolution

 

 

Morning, Sunday, September 13th.

Mini-Symposium 5

New Processes in Drug Discovery

Workshop 7

Drug Delivery

Workshop 9

Challenges and Perspectives in Natural Products

Round Table

The Impact of Megamergers on Drug Research and Development

Plenary Lecture 3

Recombinant DNA Technology And Vaccine Development

Poster Sessions

8, 9, 10, 11, 12

 

 

Afternoon, Sunday, September 13th.

Round Table

Natural Food Modified by Biotechnology:
Nutritional and Pharmaceutical Issues

Workshop 8

Cell Lines and Tissue Culture in Drug Discovery and Development

Workshop 6

Pharmaceutical Technology:
Material Science

9.30-12.00 FRIDAY, September 11

 

9.30 - 9.50

OPENING REMARKS

9.50 - 10.00

AWARD IN HONOR OF PROF. SEGRE

 

PLENARY LECTURE 1

 

10.00 - 10.45

Shankley N.P., Black J.W. (London, UK)
RECEPTORS AS DRUG TARGETS

10.45 - 11.15

Break

 

PLENARY LECTURE 2

 

11.15 - 12.00

Breimer D.D. (Leiden, The Netherlands)
CHALLENGES FOR DRUG DELIVERY

12.00

End of the Session

 

 

 

 

Display
08.30 - 18.30
Discussion
13.00 - 14.30

Poster Session 1 - Drug Discovery: New Processes
Poster Session 2 - Drug Discovery: New Targets
Poster Session 3 - Drug Development: Chemical Synthesis
Poster Session 4 - Drug Development: Analytical Characterization
Poster Session 5 - Issues in Clinical Pharmacy

index

 

14.30-18.00 FRIDAY, September 11

 

ROUND TABLE

GENERIC DRUGS AND INTELLECTUAL PROPERTY
RIGHTS IN THE GLOBAL PHARMACEUTICAL MARKET

 

14.30 - 14.45

De Jong H.J. (Courbevoie, France)
INDUSTRIAL PERSPECTIVES

14.45 - 15.00

Bass R. (London, UK)
EMEA PERSPECTIVES

15.00 - 15.15

Bianchetti G. (Milan, Italy)
INTELLECTUAL PROPERTY ISSUES RELEVANT FOR GENERIC AND "BULK" MANUFACTURERS

15.15 - 15.30

Fleischer N. (Washington, USA)
FDA PERSPECTIVES

15.30 - 16.30

General Discussion

16.30 - 17.00

Break

17.00 - 18.00

BRACCO PRIZE

18.00

End of the Session

index

 

14.30-16.30 FRIDAY, September 11

 

MINI-SYMPOSIUM 1

NEW TRENDS IN ALZHEIMER'S DISEASE

 

14.30 - 15.00

Hendriks L. (Antwerpen, Belgium)
ALZHEIMER'S DISEASE: FROM GENETICS TO PATHOPHYSIOLOGY

15.00 - 15.30

Govoni S. (Pavia, Italy)
BIOCHEMICAL MARKERS OF ALZHEIMER'S DISEASE

15.30 - 16.00

Bellosta S. (Milan, Italy)
USE OF TRANSGENIC MODELS IN THE EVALUATION OF NOVEL THERAPEUTIC FOR ALZHEIMER'S DISEASE

16.00 - 16.30

Bauer J. (Freiburg, Germany)
ANTI-INFLAMMATORY SUBSTANCES AS A NEW THERAPEUTIC OPTION IN ALZHEIMER'S DISEASE

16.30

End of the Session

index

 

14.30-18.00 FRIDAY, September 11

 

WORKSHOP 1

DRUG DELIVERY

(Part I)

 

14.30 - 15.00

Colombo P. (Parma, Italy)
SWELLABLE MATRICES FOR ORAL CONTROLLED RELEASE: AN UPDATE ON DELIVERY MECHANISM

15.00 - 15.15

Alhaique F. (Rome, Italy)
TWO POLYSACCHARIDES FOR CONTROLLED DRUG DELIVERY: SCLEROGLUCAN AND GELLAN

15.15 - 15.30

Rowley G. (Sunderland, UK)
RELEASE MECHANISMS FOR DRUG/POLYMER FORMULATIONS IN HARD GELATIN CAPSULES

15.30 - 15.45

Cortesi R. (Ferrara, Italy)
LIPOSOMES, MICELLES AND MICROEMULSIONS AS NEW DELIVERY SYSTEMS FOR CAMPTOTHECIN

15.45 - 16.00

Adekova V. (London, UK)
COMPARATIVE RELEASE KINETICS OF SOME CO-POLYMERIC NANOPARTICLES FOR DRUG DELIVERY

16.00 - 16.15

Sendil D. (Ankara, Turkey)
TETRACYCLINE RELEASE FROM BIODEGRADABLE POLYESTERS FOR TREATMENT OF PERIODONTAL DISEASES

16.15 - 16.45

Break

 

WORKSHOP 1

DRUG DELIVERY

(Part II)

 

16.45 - 17.00

Arunothayanun P. (London, UK)
APPROACHES TO A BIOMIMETIC DELIVERY DEVICE: RELEASE OF SINGLE NIOSOMES FROM CAPILLARIES

17.00 - 17.15

Müller R.H. (Berlin, Germany)
NANOSUSPENSIONS OF POORLY SOLUBLE CYTOTOXICS: DESIGN OF A LAB SCALE PRODUCTION UNIT

17.15 - 17.30

Walters P.A. (Sunderland, UK)
MOISTURE UPTAKE OF VEHICLES FOR LIQUID-FILLING INTO HARD GELATIN CAPSULES

17.30 - 17.45

Dobson C.L. (Nottingham, UK)
CAN INTESTINAL DELIVERY OF OLEIC ACID STIMULATE THE ILEAL BRAKE AND SLOW TABLET TRANSIT?

17.45 - 18.00

Mollee H. (Leiderdorp, The Netherlands)
THE FORMATION OF VISUALISATION OF DRIED REVERSED VESICLES AND THEIR UPTAKE IN RATS AFTER JEJUNAL ADMINISTRATION

18.00

End of the Session

index

 

14.30-18.00 FRIDAY, September 11

 

WORKSHOP 2

NEW TARGETS IN DRUG DISCOVERY

(Part I)

 

14.30 - 15.00

Pellicciari R. (Perugia, Italy)
OXIDATIVE STRESS AND EXCITOTOXICITY: MEDICINAL CHEMISTRY APPROACHES

15.00 - 15.30

Pratesi G. (Milan, Italy)
SELECTIVITY CRITERIA FOR THE IDENTIFICATION OF NEW ANTITUMOR TAXANES

15.30 - 15.45

Schunack W. (Berlin, Germany)
HISTAPRODIFEN AND N
à -SUBSTITUTED DERIVATIVES: A NEW CLASS OF SELECTIVE AND HIGHLY POTENT HISTAMINE
H
1-RECEPTOR AGONISTS

15.45 - 16.00

Volterra A. (Milan, Italy)
CIP-A, A NEW POTENT AMPA/KAINATE RECEPTOR AGONIST,INDUCES GLUTAMATE RELEASE IN ASTROCYTES: COMPARISON WITH AMPA

16.00 - 16.15

Sasse A. (Berlin, Germany)
CHEMICAL AND PHARMACOLOGICAL INVESTIGATION ON CHIRAL HISTAMINE H
3-RECEPTOR ANTAGONISTS

16.15 - 16.45

Break

 

WORKSHOP 2

NEW TARGETS IN DRUG DISCOVERY

(Part II)

 

16.45 - 17.00

Kleuser B. (Berlin, Germany)
SPHINGOSINE-1-PHOSPHATE, A NEW ANTIPSORIATIC DRUG

17.00 - 17.15

Rastelli G. (Modena, Italy)
ADENOSINE A2A RECEPTOR: MOLECULAR MODELLING OF THE INTERACTIONS WITH AGONISTS AND ANTAGONISTS

17.15 - 17.30

Gütschow M. (Leipzig, Germany)
INHIBITION OF HUMAN LEUKOCYTE ELASTASE BY THIENO [2,3-
d ] [1,3]OXAZIN-4-ONES

17.30 - 17.45

Ecker G. (Vienna, Austria)
STUDIES ON PROPAFENONE-TYPE MODULATORS OF MULTIDRUG RESISTANCE: INFLUENCE OF HYDROPHOBICITY DISTRIBUTION

17.45 - 18.00

Cacciari B. (Ferrara, Italy)
SECOND GENERATION OF A
2A ADENOSINE RECEPTOR ANTAGONISTS: SYNTHESIS AND BIOLOGICAL EVALUATION

18.00

End of the Session

index

 

9.00-12.30 SATURDAY, September 12

 

WORKSHOP 3

DRUG TARGETING

(Organ Selectivity - Cell Targeting - Cell Signalling)

(Part I)

 

9.00 - 9.30

Schechter B. (Rehovot, Israel)
IMMUNOTARGETING AND TISSUE/ORGAN DELIVERY USING THE AVIDIN-BIOTIN SYSTEM

9.30 - 10.00

Scheideler M.A. (Baranzate di Bollate, Italy)
EVIDENCE FOR MULTIPLE STRUCTURAL DETERMINANTS REQUIRED FOR THE ACTIVATION OF G-PROTEIN COUPLED RECEPTORS

10.00 - 10.15

Waterworth C.A. (Cardiff, UK)
TWO-LEVEL FACTORIAL ANALYSIS OF THE ROLE OF CHARGE AND NEUTRAL LIPID COMPOSITION ON THE IN-VITRO TRANSFECTION EFFICIENCY OF LIPOSOME-plasmid DNA (pDNA) COMPLEXES

10.15-10.30

Jääskeläinen J. (Kuopio, Finland)
ROLE OF FUSOGENIC DOPE IN CATIONIC LIPOSOME MEDIATED DELIVERY OF OLIGONUCLEOTIDES INTO CELLS

10.30 - 10.45

Dahlin M. (Uppsala, Sweden)
BRAIN TARGETING VIA NASAL ADMINISTRATION

10.45 - 11.30

Break

 

WORKSHOP 3

DRUG TARGETING

(Organ Selectivity - Cell Targeting - Cell Signalling)

(Part II)

 

11.30 - 11.45

Gabor F. (Vienna, Austria)
DOXORUBICIN-TARGETING TO COLON CARCINOMA CELLS BY MEANS OF WHEAT GERM AGGLUTININ

11.45 - 12.00

Frahm A.W. (Freiburg, Germany)
SUBSTITUTED XANTHONES AS ANTIMYCOBACTERIAL AGENTS: SYNTHESIS, MICROBIOLOGY AND QSAR

12.00 - 12.15

Takakura Y. (Kyoto, Japan)
EFFICIENT GENE EXPRESSION AND ANTITUMOR EFFECT FOLLOWING DIRECT INJECTION OF INTERFERON-
g GENE INTO SOLID TUMORS

12.15 - 12.30

Severin E.S. (Moscow, Russia)
EPIDERMAL GROWTH FACTOR (EGF) CONJUGATE WITH DOXORUBICINE (DR) PRODUCES TOXIC EFFECT ON ANTIBIOTIC RESISTANT TUMOR CELL CULTURES

12.30

End of the Session

index

 

9.00-12.30 SATURDAY, September 12

 

MINI-SYMPOSIUM 2

NEW PERSPECTIVES IN ANALYTICAL CHEMISTRY

(Part I)

 

9.00 - 9.30

Fell A.F. (Bradford, UK)
HYPHENATED SYSTEMS IN PHARMACEUTICAL RESEARCH AND DEVELOPMENT

9.30 - 10.00

Traldi P. (Padua, Italy)
THE EVOLUTION OF MASS SPECTROMETRY AND ITS IMPACT ON PHARMACEUTICAL ANALYSIS

10.00 - 10.30

Gasparrini F. (Rome, Italy)
THE CHIRAL DIMENSION IN DRUG RESEARCH ANALYSIS

10.30 - 11.00

De Lorenzi E. (Pavia, Italy)
THE IMPACT OF CAPILLARY ELECTROPHORESIS IN DRUG ANALYSIS AND BIOANALYSIS

11.00 - 11.30

Break

 

MINI-SYMPOSIUM 2

NEW PERSPECTIVES IN ANALYTICAL CHEMISTRY

(Part II)

 

11.30 - 12.00

Jezequel S.G. (Sandwich, UK)
BIOANALYTICAL STRATEGIES IN ADME: PRESENT NEEDS AND CHALLENGES FOR THE FUTURE

12.00 - 12.30

Garner R.C. (Sand Hutton, UK)
BIOMEDICAL ACCELERATOR MASS SPECTROMETRY FOR ATTOMOLE SENSITIVITY IN DRUG BIOANALYSIS

12.30

End of the Session

index

 

9.00-11.00 SATURDAY, September 12

 

SYMPOSIUM

DRUGS AND CANCER:
Experimental and Clinical Pharmacology of Tumours and Apoptosis

 

Chairpersons:

G.F. Draetta (Milan, Italy)

G. Melino (Rome, Italy)

9.00 - 9.30

Hickman J. (Manchester, UK)
APOPTOSIS AND PHARMACOLOGICAL THERAPY OF CANCER

9.30 - 10.00

Evan G. (London, UK)
CANCER: A MATTER OF LIFE AND CELL DEATH

10.00 - 10.30

Delia D. (Milan, Italy)
APOPTOSIS AND RESISTANCE TO PHARMACOLOGICAL TUMOR THERAPY

10.30 - 11.00

Scambia G. (Rome, Italy)
APOPTOSIS AND PHARMACOLOGICAL THERAPY OF GYNAECOLOGICAL TUMOR

11.00

End of the Session

11.00 - 11.30

Break

index

 

11.30 - 12.30 SATURDAY, September 12

 

SYMPOSIUM

THE 5TH FRAMEWORK PROGRAMME:
PERSPECTIVES AND IMPACT ON EUROPEAN RESEARCH

 

Chairpersons:

U. Scapagnini (Brussels, Belgium)

P. Fasella (Rome, Italy)

11.30 - 11.50

Scapagnini U. (Brussels, Belgium)
THE EUROPEAN PARLIAMENT ACTIVITIES FOR IMPROVING INNOVATION AND RTD ACTIVITIES IN THE EU

11.50- 12.10

Bertazzoni U. (Brussels, Belgium)
NEW APPROACH AND CONTENTS OF THE "QUALITY OF LIFE" THEMATIC PROGRAMME OF THE FIFTH RTD FRAMEWORK PROGRAMME OF THE EUROPEAN COMMISSION

12.10 - 12.30

Damiani A. (Brussels, Belgium)
THE NEW RULES FOR PARTICIPATION AND FOR DISSEMINATION AND EXPLOITATION OF RESULTS IN THE FORTHCOMING FIFTH RTD FRAMEWORK PROGRAMME

12.30

End of the Session

index

9.00-11.00 SATURDAY, September 12

 

SYMPOSIUM

NEW TRENDS IN
BIOAVAILABILITY - BIOEQUIVALENCE STUDIES

 

Chairpersons:

L.P. Balant (Geneve, Switzerland)

C.M. Caramella (Pavia, Italy)

9.00 - 9.20

Blume H.H. (Karlsruhe, Germany)
WHEN ARE BIOAVAILABILITY-BIOEQUIVALENCE STUDIES NECESSARY?

9.20 - 9.40

Grahnén A. (Uppsala, Sweden)
THE BIOPHARMACEUTICAL CLASSIFICATION SYSTEM - IMPACT FOR DRUG DEVELOPMENT

9.40 -10.00

Marzo A. (Ligornetto, Switzerland)
OPEN QUESTIONS ON BIOEQUIVALENCE: SOME PROBLEMS AND SOME SOLUTIONS

10.00 - 10.10

General Discussion

10.10 - 10.30

Gomeni R. (Cergy, France)
INDIVIDUAL BIOEQUIVALENCE

10.30 - 10.50

Canali S. (Colleretto Giacosa, Italy)
BIOAVAILABILITY/BIOEQUIVALENCE OF BIOTECH DERIVED PRODUCTS

10.50 - 11.00

General Discussion

11.00

End of the Session

 

 

 

 

Display
08.30 - 18.30
Discussion
13.00 - 14.30

Poster Session 6 - Drug Discovery: Pharmacological and Therapeutic Advances
Poster Session 7 - Drug Development: Delivery Systems

index

 

 

14.30-18.00 SATURDAY, September 12

 

WORKSHOP 4

DRUG METABOLISM AND PHARMACOKINETICS

(Part I)

 

14.30 - 15.00

Ings R.M.J. (Nerviano, Italy)
THE PREDICTION OF HUMAN PHARMACOKINETICS AND PHARMACODYNAMICS FROM ANIMAL DATA

15.00 - 15.30

Sirtori C.R. (Milan, Italy)
PHARMACOKINETICS AND PHARMACODYNAMICS: CLINICAL POINT OF VIEW

15.30 - 15.45

Einer-Jensen N. (Odense, Denmark)
PREFERENTIAL DISTRIBUTION TO THE BRAIN OF DIAZEPAM, BUT NOT OF COCAINE, AFTER NASAL APPLICATION IN THE RAT

15.45 - 16.00

Iavarone L. (Verona, Italy)
PHARMACOKINETIC/PHARMACODYNAMIC RELATIONSHIPS FOR SANFETRINEM IN A MURINE THIGH INFECTION MODEL

16.00 - 16.15

Goldsmith P. (Manchester, UK)
CONSTRUCTION OF A STEREOCHEMICAL & PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL OF THREE BETA ADRENERGIC ANTAGONISTS

16.15 - 16.30

Della Paschoa O.E. (Leiden, The Netherlands)
PK/PD MODELLING OF THE BEHAVIOURAL EFFECTS OF S-15535 AND ITS METABOLITE S-32784 IN RATS

16.30 - 17.00

Break

 

WORKSHOP 4

DRUG METABOLISM AND PHARMACOKINETICS

(Part II)

 

17.00 - 17.15

Courtney R.D. (Manchester, UK)
INFLUENCE OF PROTEIN BINDING ON HEPATIC DISTRIBUTION KINETICS OF ANTISENSE OLIGONUCLEOTIDES

17.15 - 17.30

Bernareggi A. (Monza, Italy)
COMPARATIVE PHARMACOKINETICS OF BBR 3464, CISPLATIN (CDDP) AND CARBOPLATIN (CBDCA) AT ACTIVE DOSES IN THE MOUSE

17.30 - 18.00

Mazzei T. (Florence, Italy)
PHARMACODYNAMIC AND PHARMACOKINETIC CONSIDERATIONS REGARDING NEW FLUOROQUINOLONES

18.00

End of the Session

index

 

14.30-18.00 SATURDAY, September 12

 

WORKSHOP 5

CHEMICAL DEVELOPMENT AND
DRUG CHARACTERIZATION
(Part I)

 

14.30 - 15.00

Villa M. (Bresso, Italy)
SCALE-UP IN DRUG MANUFACTURE: PROCESS DEVELOPMENT AND OPTIMIZATION

15.00 - 15.30

Bannister R. (Cambridge, UK)
CHIRALITY IN DRUG DEVELOPMENT AND BULK DRUG SUPPLY

15.30 - 16.00

Nebuloni M. (Cologno Monzese, Italy)
POLYMORPHISM AND SCALE-UP

16.00 - 16.30

Miller J. (Strasbourg, France)
CHARACTERISATION OF DRUG REFERENCE STANDARDS: REGULATORY APPROACH

16.30 - 17.00

Break

 

WORKSHOP 5

CHEMICAL DEVELOPMENT AND
DRUG CHARACTERIZATION
(Part II)

 

17.00 - 17.15

Massolini G. (Pavia, Italy)
CAPILLARY ELECTROPHORESIS INVESTIGATION ON PUTATIVE BINDING DRUGS FOR A POTENTIAL NEW THERAPEUTIC APPROACH IN DIALYSIS RELATED AMYLOIDOSIS

17.15 - 17.30

Jee R.D. (London, UK)
DRUG IDENTIFICATION USING THE MAJOR 2ND DERIVATIVE NEAR-INFRARED PEAKS

17.30 - 17.45

Caron G. (Turin, Italy)
pH-METRIC METHOD AS A POWERFUL TOOL TO INVESTIGATE DRUG MOLECULAR PHYSICOCHEMICAL DESCRIPTORS

17.45 - 18.00

Viernstein H. (Vienna, Austria)
FREE ENERGY PREDICTION OF THE HOST-GUEST COMPLEXATION OF VARIOUS CYCLODEXTRINS

18.00

End of the Session

index

 

14.30-16.30 SATURDAY, September 12

 

MINI-SYMPOSIUM 3

ROUTES FOR SITE-SPECIFIC DELIVERY

 

14.30 - 15.00

Martin G.P. (London, UK)
THE DEVELOPMENT OF POLYMERS FOR TARGETED DELIVERY OF DRUGS TO THE COLON

15.00 - 15.30

Davis S.S. (Nottingham, UK)
PULMONARY AND NASAL ROUTES OF DELIVERY

15.30 - 16.00

Guy R.H. (Archamps, France and Genève, Switzwerland)
TRANSDERMAL DRUG DELIVERY: OVERCOMING SKIN'S BARRIER FUNCTION

16.00 - 16.30

General Discussion

16.30

End of the Session

index

 

14.30-16.30 SATURDAY, September 12

 

MINI-SYMPOSIUM 4

BIOTECHNOLOGY DRUGS AND THE
THERAPEUTIC REVOLUTION

 

14.30 - 15.00

Calam D.H. (Potters Bar, UK)
FUTURE PERSPECTIVES FOR BIOTECHNOLOGY PRODUCTS: REGULATORY AND THERAPEUTIC IMPLICATIONS

15.00 - 15.30

Hancock W.S. (Palo Alto, USA)
THE USE OF HPLC AND HPCE COUPLED TO MASS SPECTROMETRY TO CHARACTERISE THE PURITY AND SAFETY OF BIOTECHNOLOGY DRUGS

15.30 - 16.00

Vicari G. (Rome, Italy)
SAFETY ASPECTS OF BIOTECHNOLOGICALLY-DERIVED PRODUCTS

16.00 - 16.30

Galligani L. (Munich, Germany)
EUROPEAN PATENTS IN THE BIOTECHNOLOGICAL FIELD: RELEVANT DECISIONS OF THE BOARDS OF APPEAL OF THE EUROPEAN PATENT OFFICE

16.30

End of the Session

index

 

9.00-12.30 SUNDAY, September 13

 

MINI-SYMPOSIUM 5

NEW PROCESSES IN DRUG DISCOVERY

 

9.00 - 9.30

Broach J.R. (Princeton, USA)
HTS: A TOOL FOR KNOWLEDGE AND LEAD DISCOVERY

9.30 - 10.00

Warrington B.H. (Harlow, UK)
RECENT PROGRESS IN COMBINATORIAL TECHNOLOGIES

10.00 - 10.30

Gaviraghi G. (Verona, Italy)
THE IMPACT OF NEW TECHNOLOGIES IN THE LEAD OPTIMIZATION PROCESS

10.30 - 11.00

General Discussion

11.00 - 11.30

Break

PLENARY LECTURE 3

 

11.45- 12.30

Rappuoli R. (Siena, Italy)
RECOMBINANT DNA TECHNOLOGY AND VACCINE DEVELOPMENT

12.30

End of the Session

 

 

 

 

Display
08.30 - 18.30
Discussion
13.00 - 14.30

Poster Session 8 - Drug Discovery: Natural Products
Poster Session 9 - Drug Discovery: Oxidative Damage
Poster Session 10 - Drug Development: Pharmacokinetics and Metabolism
Poster Session 11 - Drug Development: Cell Lines and Tissue Culture
Poster Session 12 - Drug Targeting

index

 

9.00-11.00 SUNDAY, September 13

 

WORKSHOP 7

DRUG DELIVERY

 

9.00 - 9.30

Veillard M. (Vitry-sur-Seine, France)
SOME PHARMACEUTICAL STRATEGIES FOR THE FORMULATION OF SPARINGLY SOLUBLE DRUGS

9.30 - 9.45

Junginger H.E. (Leiden, The Netherlands)
NOVEL CHITOSAN DERIVATIVES AS POLYMERIC CARRIERS FOR PEPTIDE AND PROTEIN DRUG DELIVERY

9.45 - 10.00

Tukker J.J. (Utrecht, The Netherlands)
RELEVANCE OF THE PEPTIDE-BOND CARBONYL FOR AFFINITY FOR THE SMALL-PEPTIDE CARRIER

10.00 - 10.15

Murdan S. (London, UK)
INVERSE TOROIDAL VESICLES: THE PRECURSORS OF TUBULAR STRUCTURES IN SORBITAN MONOSTEARATE ORGANOGELS

10.15 - 10.30

Cassidy O. (Sunderland, UK)
ELECTROSTATIC CHARGE AND DISSOLUTION OF SURFACE MODIFIED PHENYLBUTAZONE

10.30 - 10.45

Sarciaux J.-M. (West Lafayette, USA)
PHYSICAL STABILITY OF IgG DURING LYOPHILIZATION

10.45 - 11.00

Komarek P. (Prague, Czech Republic)
PHOTOACTIVATED PROTEINS LABELLED WITH TECHNETIUM-99mTc USING REDOX POLYMERS: A NEW APPROACH TO RADIOPHARMACEUTICAL PREPARATION

11.00

End of the Session

index

 

9.00-11.20 SUNDAY, September 13

 

WORKSHOP 9

CHALLENGES AND PERSPECTIVES IN
NATURAL PRODUCTS

 

9.00 - 9.30

Kolb H.C. (Basel, Switzerland)
DESIGN AND SYNTHESIS OF POTENT E-SELECTIN ANTAGONISTS

9.30 - 9.45

Gagliardi S. (Baranzate di Bollate, Italy)
SYNTHESIS OF FLUORESCENT DERIVATIVES OF BAFILOMYCIN A
1 AS PROBES FOR THE VACUOLAR ATPase

9.45 - 10.00

Visioli F. (Milan, Italy)
FREE RADICAL-SCAVENGING ACTIVITY OF OLIVE OIL PHENOLICS

10.00 - 10.15

Roberti M. (Bologna, Italy)
METHOXYLATED ANALOGUES OF COCAINE: IDENTIFICATION OF A WEAK "ANTAGONIST"

10.15 - 10.45

Maffei Facino R. (Milan, Italy)
ANTIOXIDANT PROPERTIES OF GRAPE PROCYANIDINS

10.45 - 11.00

Syrovets T. (Ulm, Germany)
IDENTIFICATION OF POTENT PHARMACODYNAMIC PROPERTIES OF BOSWELLIC ACIDS

11.00 - 11.20

Benatti P. (Pomezia, Italy)
CARNITINE SYSTEM AND PERIPHERAL ARTERIAL DISEASE

11.20

End of the Session

index

 

9.00-11.00 SUNDAY, September 13

 

ROUND TABLE

THE IMPACT OF MEGAMERGERS ON
DRUG RESEARCH AND DEVELOPMENT

 

Chairpersons:

L.M. Fuccella (Milan, Italy)

R. Paoletti (Milan, Italy)

9.00 - 9.15

Ando G. (Bridgewater, USA
WHAT FUTURE FOR DRUG RESEARCH?

9.15 - 9.30

Cattani L. (Rome, Italy)
THE ECONOMIC IMPACT

9.30 - 9.45

Pepeu G. (Florence, Italy)
IS THERE STILL A ROLE FOR ACADEMIA?

9.45 - 10.00

Benzi G. (London, UK)
THE ROLE OF EUROPEAN INSTITUTIONS

10.00 - 10.15

Dompe' S. (Milan, Italy)
IS THERE STILL A ROLE FOR NATIONAL INDUSTRIES?

10.15 - 10.30

Criscuolo D. (Milan, Italy)
THE ROLE OF ITALY IN DEVELOPMENT

10.30 - 11.00

General Discussion

11.00

End of the Session

index

 

14.30-16.30 SUNDAY, September 13

 

ROUND TABLE

NATURAL FOOD MODIFIED BY BIOTECHNOLOGY:
NUTRITIONAL AND PHARMACEUTICAL ISSUES

 

Chairpersons:

U. Bracco (Vevey, Switzerland)

A. Poli (Milan, Italy)

 

14.30 - 15.00

Turk S.C.H.J. (Utrecht, The Netherlands)
FRUCTAN ACCUMULATION IN TRANSGENIC PLANTS

15.00 - 15.30

Petiard V. (Notre Dame D'Oe, France)
PLANT BIOTECHNOLOGIES FOR THE PRODUCTION OF ACTIVE COMPOUNDS BY CELL CULTURES AND WHOLE PLANTS

15.30 - 16.00

Schrott M. (Zurich, Switzerland)
BIOTECHNOLOGY: A TOOL TO INTRODUCE BIOACTIVE COMPOUNDS IN CEREALS

16.00 - 16.30

Schuch W. (Bracknell, UK)
ENHANCING NUTRIENT CONTENTS OF FOOD AND FEED CROPS USING BIOTECHNOLOGY

16.30

End of the Session

index

 

14.30-16.30 SUNDAY, September 13

 

WORKSHOP 8

CELL LINES AND TISSUE CULTURE IN
DRUG DISCOVERY AND DEVELOPMENT

 

14.30 - 15.00

Artursson P. (Uppsala, Sweden)
REFINED METHODS FOR PREDICTION OF INTESTINAL DRUG ABSORPTION

15.00 - 15.15

Lane M.E. (Dublin, Ireland)
CORRELATION BETWEEN PERMEABILITY CO-EFFICIENTS IN A PERFUSED RAT MODEL AND THE CACO-2 CELL MODEL

15.15 - 15.30

Verspohl E.J. (Münster, Germany)
DUAL EFFECTS OF DIADENOSINE POLYPHOSPHATES ON INS-1 CELLS

15.30 - 15.45

Forbes B. (London, UK)
TRANSPORT CHARACTERISTICS OF FORMOTEROL AND SALBUTAMOL ACROSS A BRONCHIAL EPITHELIAL DRUG ABSORPTION MODEL

15.45 - 16.00

Shen W.C. (Los Angeles, USA)
INSULIN ABSORPTION VIA TRANSFERRIN RECEPTOR-MEDIATED TRANSCYTOSIS IN INTESTINAL EPITHELIUM

16.00 - 16.15

Bertolotti L. (Verona, Italy)
EVALUATION OF AN IN VITRO MODEL OF BLOOD-BRAIN BARRIER TO ASSESS THE DRUG TRANSPORT INTO THE BRAIN

16.15 - 16.30

Jacques Y. (Archamps, France)
HEAT SEPARATED BUCCAL EPITHELIUM: A MODEL FOR STUDYING THE PERMEABILITY OF ORAL MUCOSA

16.30

End of the Session

index

 

14.30-16.45 SUNDAY, September 13

 

WORKSHOP 6

PHARMACEUTICAL TECHNOLOGY:
MATERIAL SCIENCE

 

14.30 - 15.00

York P. (Bradford, UK)
STRATEGIES FOR PARTICLE DESIGN USING SUPERCRITICAL FLUID TECHNOLOGIES

15.00 - 15.15

Martini A. (Milan, Italy)
ESTRAMUSTINE PHOSPHATE/BETA-CYCLODEXTRIN FORMULATION: RATIONALE, FORMULATION DEVELOPMENT AND BIOAVAILABILITY

15.15 - 15.30

Michalski L.A. (Nottingham, UK)
IN VITRO EVALUATION OF COLONIC DRUG DELIVERY SYSTEM BASED ON A DISULPHIDE-LINKED POLYMER

15.30 - 15.45

Bani M. (Bresso, Italy)
PHARMACOKINETICS OF 5'ASA ADMINISTERED TO HEALTHY VOLUNTEERS USING THE TIME CLOCK DELIVERY SYSTEM

15.45 - 16.00

Carli F. (Trieste, Italy)
ANTIINFLAMMATORY DRUG - BETACYCLODEXTRIN COMPOSITE BY MECHANOCHEMISTRY

16.00 - 16.30

YOUNG INVESTIGATOR AWARD

16.30 - 16.45

CLOSING REMARKS

index

 

In recognition of the importance of original work presented in the Poster Sessions, a number of new EUFEPS Young Investigator Awards will be presented for outstanding research achievements by young scientists, 32 years old or less, who submit an Abstract for this competition. Selection will be based on originality, importance of work accomplished, quality of experimental design and methodology, strength and reliability of data. The winners will be selected and notified during the Congress. Each will receive a certificate and a grant (corresponding to the Registration Fee) during the Young Investigator Award Ceremony.

 

ORGANIZING SECRETARIAT

Further information on any aspect of the organization of EUFEPS '98 can be obtained from the Secretariat in Milan:

EUFEPS '98
FONDAZIONE GIOVANNI LORENZINI MEDICAL SCIENCE FOUNDATION
Via Appiani, 7
20121 MILAN, Italy

Phone: (+39-2) 29.00.62.67*
Fax: (+39-2) 29.00.70.18*
E-Mail: lorenzfo@icil64.cilea.it

* Important Notice
Please note that from mid-June the Italian Telephone System (National and International) will be modified. If you have any difficulties in reaching us, please contact the international operator in your country.

For inquiries in USA and CANADA, please contact:

EUFEPS '98
GIOVANNI LORENZINI MEDICAL FOUNDATION
HOUSTON, USA

Phone: (+1-713) 797.0401
Fax: (+1-713) 796.8853
E-Mail: ajackson@bcm.tmc.edu

 

 
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