PharmWeb

Dr Jill Barber


Research

The molecular basis of drug action and the design of novel drugs
In particular I am interested in the antibacterial and antiparasitic action of polyketide inhibitors of protein biosynthesis

Techniques used include:

NMR spectroscopy
Isotopic labelling
Protein engineering and expression
Protein chemistry
Molecular modelling
In collaboration with groups at UMIST and Daresbury my group is involved with electrospray mass spectrometry and circular dichroism spectroscopy

Teaching

Antibiotic action
Spectroscopy
Basic biochemistry

Administration

Elected member of Senate
Member of University Committee for Policy on Undergraduate Education
Member of Faculty Review Committee
Secretary of Departmental Genetic Manipulation Committee
Member of Departmental Safety Committee
Member of Departmental Teaching and Examinations Committee
Senior Internal Examiner for Medicinal Chemistry
Supervisor for Departmental NMR Facility

Qualifications

B.A. (Hons) Natural Sciences, University of Cambridge, 1977
M.A. 1981
Ph.D. Bio-organic Chemistry, University of Cambridge, 1980
M.A., D.Phil., University of Oxford (by incorporation), 1984
M.R.S.C., C.Chem. 1986

Society Membership

Royal Society of Chemistry
Biochemical Society

Brief Career Details

Senior Lecturer, Department of Pharmacy, 1993 - present
Lecturer, 1986 - 93
Demonstrator, Department of Biochemistry, University of Oxford, 1983 - 5.
Post-doctoral research associate, Department of Nuclear Medicine, University of Heidelberg, 1982 - 83
Post-doctoral fellow, Department of Organic Chemistry, University of Karlsruhe, 1980 - 82

Recent Publications

The 1H and 13C NMR Spectra of Spiramycin I in Organic and Aqueous Solutions
P. Alam, J. Barber, R.J. Brennan, K. Kennedy and M.H.H. Tehrani
Magn. Reson. Chem. (1995), 33, 228-231

Structural Studies on Erythromycin A Enol Ether: Full Assignments of the 1H and 13C NMR Spectra
P. Alam, P.C. Buxton, J.A. Parkinson and J. Barber
J. Chem. Soc. Perkins Trans. 2 (1995), 1163-1167

Conformational Analysis of the Erythromycin Analogues Azithromycin and Clarithromycin in Aqueous Solution and Bound to Bacterial Ribosomes
A. Awan, R.J. Brennan, A.C. Regan and J. Barber
J. Soc. Chem. Commun. (1995), 1653-1654

Conformational Analysis
J. Barber and B. Wood
Chapter 11 in "Specialist Periodical Reports, Nuclear Magnetic Resonance" vol. 24, Ed. G.A. Webb, Royal Society of Chemistry, 362-397

The Antimalarial Activity of Berberine and Some Synthetic Analogues
N. Silikas, D.L.C. McCall, D. Sharples, W.M. Watkins, R.D. Waigh and J. Barber
Pharm. Sci. (1996), 2, 55-58

Further Information

Tel:. +44 (0) 161 275 2369
Fax: +44 (0) 161 275 2396
E-mail Jill.Barber@man.ac.uk


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