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Dr D G Allison


Research
Bacterial biofilm physiology
Bacterial adhesion to surfaces
Extracellular matrix production
Infectivity and virulence of opportunistic lung pathogens
Bacterial cell-cell signalling (QSTA)

Teaching
Pharmaceutical Microbiology - introductory microbiology, sterilisation processing
Quality Assurance - environmental control, cleanroom design, microbial monitoring
Antimicrobial Chemotherapy - antibiotic mode of action, bacterial resistance mechanims
Microbial Pathogenicity - bacterial growth in vivo, virulence factor production, resistance to host defences
Fermentation Biotechnology - strain selection,cell culture, fermenter design, product recovery

Administration
Secretary to the School Board
Member of the Staff/Student Committee
Member of the Curriculum Committee
Module tutor on the Pharmaceutical Industry Advanced Training Programme PIAT

Qualifications
B.Sc.(Hons) Biological Science, Upper Second Class. University of Edinburgh, 1977 - 1981.
Ph.D Microbial Physiology, University of Edinburgh, 1981 - 1984

Society Membership
American Association for Microbiology
Society for General Microbiology
Society for Applied Bacteriology
British Biofilm Club
Parenteral Society of Great Britain

Brief Career Details
Lecturer, School of Pharmacy and Pharmaceutical Sciences (1990 - present)
Visiting scientist, Department of Microbiology and Immunology, University of Illinois, Chicago, USA (1992)
Postdoctoral Research Fellow, Pharmaceutical Sciences Institute, Aston University, Birmingham, England, (1987 - 1989)
Postdoctoral Research Fellow, Zeneca (nee ICI) Pharmaceuticals, Alderley Edge, England, (1984 - 1987)

Recent Publications

ALLISON, D.G. & GILBERT, P. (1996). Redefining the 'sterility' of sterile products. European Journal of Parenteral Sciences, 1: 19-23.

McKENNEY, D., BROWN, K.E. & ALLISON, D.G. (1995). Influence of Pseudomonas aeruginosa exoproducts on virulence factor production in Burkholderia cepacia: evidence of interspecies communication. Journal of Bacteriology, 177: 6989-6992.

WILLIAMS, K.A., CLARK, H.A. & ALLISON, D.G. (1995). Use of ultrasound to facilitate antibiotic diffusion through Pseudomonas aeruginosa alginate. Journal of Antimicrobial Chemotherapy, 36: 463-473.

McKENNEY, D. & ALLISON, D.G. (1995). Effects of growth rate and nutrient limitation on virulence factor production in Burkholderia cepacia. Journal of Bacteriology, 177: 4140-4143.

ALLISON, D.G. & GILBERT, P. (1994). Bacterial biofilms. Science Progress 76: 305-321.

Biography

David ALLISON was appointed as a lecturer in Pharmaceutical Microbiology in the Department of Pharmacy at The University of Manchester in January 1990. His first degree was in Microbiology at Edinburgh University, as were his postgraduate studies in Microbial Physiology where he studied the role of bacterial exopolysaccharides in cell adhesion. On leaving Edinburgh in 1984 he emigrated to join ICI Pharmaceuticals, Macclesfield, England, for a three year postdoctoral period investigating the production and role of ß-lactam antibiotics in bacteria. This was followed by a further period of postdoctoral research, at Aston University, Birmingham, England, on the properties and surface antigenicity of clinically important adherent bacterial populations.

Dr Allisons main research interests are two-fold. The first area centres on the infectivity and virulence properties of opportunistic lung pathogens. In particular, work on bacterial infections in patients with fibrocystic (CF) lung disease features various aspects associated with the microbiology of lung tissue colonisation, including cell-cell communication, extracellular matrix production and resistance to antibiotics.

The second area of interest concerns the production of biofilm-specific matrix polymers in adherent bacterial populations. Avenues under investigation include polymer characterisation, the role of such polymers in adhesion, and mechanisms of prevention\inhibition.

Further Information
Tel: +44 (0)161 275 2359
FAX: +44 (0)161 275 2396
E-mail: DAllison@fs1.pa.man.ac.uk


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PharmWeb - Copyright©1994-1998. All rights reserved  ÌÌ>- Dr L J Aarons
pharmweb232.htmlumentsirect)-syTEXTHtMlÿÿÿÿ½àpÿõ²«QoŽ r> Research: Pharmacokinetics/pharmacodynamics, particularly data analysis and populations.

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