PharmWeb

Dr S Freeman


Research

Bioorganic phosphorus chemistry:
Synthesis and evaluation of biologically active inositol phosphates
Prodrug methodology for the cellular delivery of drugs containing phosphate or phosphonate groups
Synthesis and evaluation of carbohydrate phosphate analogues
Synthesis of inhibitors and alternative substrates for enzymatic reactions

Teaching

Organic and medicinal chemistry

Administration

Secretary of Staff / UG Student committee
President of the Manchester University Pharmaceutical Society
Member of the Postgraduate Affairs Group
Member of the Lister Institute

Qualifications

BSc Chemistry (Hons) First Class, Leicester University, 1982
PhD, Organophosphorus Chemistry, Leicester University, 1985

Society Membership

Royal Society of Chemistry, CChem, MRSC

Brief Career Details

Lecturer and Lister Fellow in Medicinal Chemistry, Department of Pharmacy (1994 - present)
Lecturer and Lister Fellow, Department of Pharmaceutical Sciences, Aston University (1987 - 1994)
Visiting scientist, Cancer Research Institute and Department of Chemistry (Professor GR Pettit), Arizona State University, USA (1994)
Visiting scientist, Department of Chemistry (Professor JR Knowles), Harvard University, USA
( 1988 - 1991)
Postdoctoral fellow, Department of Chemistry (Professor JR Knowles), Harvard University, USA ( 1985 - 1987)

Awards

Dunlop Polymer Prize (1982)
Lilly Prize for Pharmaceutical Excellence (1993)

Recent Publications

Spiers ID, Barker CJ, Chung S-K, Chang Y-T, Freeman S, Gardiner JM, Hirst PH, Lambert PA, Michell RH, Poyner DR, Schwalbe CH, Smith AW, Solomons KRH.
Synthesis and iron binding studies of myo-inositol 1,2,3-trisphosphate and D/L-myo-inositol 1,2-bisphosphate, and iron binding studies of all myo-inositol tetraphosphates.
Carbohydr. Res, 1996, 282, 81-89

Spiers ID, Freeman S, Schwalbe CH.
Crystal structure and modelling studies of myo-inositol 1,2,3-trisphosphate.
J. Chem. Soc. Chem. Commun., 1995, 2219-2220.

Routledge A, Walker I., Freeman S, Hay A, Mahmood N.
Synthesis, bioactivation and anti-HIV activity of 4-acyloxybenzyl bis(nucleosid-5'-yl) phosphates.
Nucleosides and Nucleotides, 1995, 14, 1545-1558.

Chawla S, Dixon HBF, Freeman S, Smith AW.
Synthesis of 3-arsonopyruvate and its interaction with phosphoenolpyruvate mutase.
Biochem. J., 1995, 308, 931-935.

Pettit GR, Freeman S, Simpson MJ, Thompson MA, Boyd MR, Williams MD, Pettit III GR, Doubek DL.
Antineoplastic agents 320: Synthesis of a practical pancratistatin prodrug.
Anticancer Drug Design, 1995, 10, 243-250.

Spiers ID, Freeman S, Poyner DR, Schwalbe CH.
The first synthesis and iron binding studies of the natural product, myo-inositol 1,2,3-trisphosphate.
Tetrahedron Letters, 1995, 36, 2125-2128.

Ross KC, Rathbone DL, Thomson W, Freeman S.
Use of bis[2-(trialkylsilyl)ethyl] N,N-dialkylphosphoramidities for the synthesis of phosphate monoesters.
J. Chem. Soc., Perkin Trans. 1, 1995, 421-426.

Further Information
Tel: +44 (0)161 275 2366
FAX: +44 (0)161 275 2396
E-mail: SFreeman@fs1.pa.man.ac.uk


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