![]() | Fourth International Conference onDrug AbsorptionTowards Prediction and Enhancement of Oral Drug Absorption in Man | ![]() |
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Welcome and Introduction
Laurie Prescott/Malcolm Rowland
The gastrointestinal tract - a modern view
Ernest Wright (USA)
Absorption of small molecules
Barry Hirst (UK)
Break - Posters
Absorption of oligonucleotides
Stanley Crooke (USA)
Absorption of macromolecules
To be announced
Efflux proteins and drug metabolism
Les Benet (USA)
Lunch - Posters
Intestinal cell monolayers - Caco2 and beyond
Per Artusson (Sweden)
Are Caco2 cells predictive of transport and/or
metabolic properties of mammalian intestinal tissues?
Werner Rubas (USA)
Whole animal models for oral drug absorption
Jennifer Dressman (Germany)
Break - Posters
Regional intestinal perfusion in humans: an approach to study molecular mechanisms of intestinal membrane transport of drugs in vivo
Hans Lennernäs (Sweden)
Non-invasive techniques to study human drug absorption
Ian Wilding (UK)
End of Session 2
Evening Reception
Biophysical models and approaches
Norman Ho(USA)/Phil Burton (USA)
Paracellular permeation
Malcolm Rowland (UK)
Active intestinal transport - peptide and monocarboxylate drugs
Akira Tsuji (Japan)
Break - Posters
Application of physicochemical methods to prediction of oral drug absorption
J Van de Waaterbeemd (Switzerland)
Drug dissolution and absorption: application to prediction and regulation
Gordon Amidon (USA)
Computational approach to potential absorption problems: analysis of human data
Christopher Lipinski (USA)
Lunch - Posters
Formulation strategies for poorly water soluble drugs
Larry Sternson (USA)
Formulation strategies for water soluble drugs
Hans Junginger (The Netherlands)
Application of the prodrug principle
Ron Borchardt (USA)
Break - Posters
Enhancing delivery of peptides/ oligonucleotides
Bob Davis (UK)
Enhancing delivery of macromolecules
To be announced
Gene therapy expression and enhancement in
the gut
Peter Daddona (USA)
End of session 4
Conference Dinner
Combinatorial screening approaches for selection of development candidates &endash; experiences within SmithKline Beecham
Phil Smith (USA)
Experiences within Glaxo Wellcome
Break
Research to policy: evolution of the BCS in regulatory decision making
Larry Lesko (USA)
Analysis of NDA and ANDA data base for validation
Ajaz Hussain (USA)
What more needs to be done? - general discussion
Closing address -
Laurie Prescott/Malcolm Rowland
12.30hrs END OF CONFERENCE
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