-------------

ONE WEEK

WORKSHOP IN

 

Advanced

Methods in

Pharmacokinetics/

Pharmacodynamics

 

Sils-Maria, Switzerland

Sunday / Friday

22nd-27th March 1998

 

Organised by:

 

PROFESSOR MALCOLM ROWLAND

UNIVERSITY OF MANCHESTER

PROFESSOR LEWIS B. SHEINER

UNIVERSITY OF CALIFORNIA

SAN FRANCISCO

 

 

A Workshop, presenting advanced aspects and applications of pharmacokinetics, pharmacodynamics and kinetic/dynamic data analysis in the medical and pharmaceutical sciences

For whom intended The Workshop is designed for those who have a good working knowledge of basic concepts in pharmacokinetics, pharmacodynamics and data analysis and who now wish to extend their knowledge further. Emphasis will be placed on relating pharmacokinetics to underlying physiological processes and to pharmacodynamics, and on the analysis and modelling of pharmacokinetic and pharmacodynamic data.

Workshop content The mornings will be devoted to lectures by Professors Rowland and Sheiner; the afternoons to small-group workshops led by experienced tutors, in which participants will solve practical problems and develop facility with the techniques and approaches discussed in the lectures. The participants are encouraged to raise questions from their experience for discussion: time is specifically reserved for such informal discussions with Professors Rowland and Sheiner.

A book, comprising lecture outlines, derivations, problem sets with answers, and additional reading material will be provided. Participants should come with a scientific hand calculator.

Topics to be covered include:

1. Review of basic concepts.

2. Empirical models for Pharmacokinetics (sums of exponentials) and Pharmacodynamics (hyperbolic).

3. Mechanistic models for Pharmacokinetics

(compartmental, physiological) and Pharmaco-

dynamics (receptor-theory) and combined kinetics/

dynamics (effect-compartment indirect)

4. Data analysis techniques for empirical or mechanistic modelling: point estimates, confidence intervals, hypothesis tests.

5. Non-parametric models for pharmacokinetics (linear systems) and pharmacodynamics; and associated data analysis techniques.

 

Main Organisers

MALCOLM ROWLAND

Malcolm Rowland is Professor of Pharmacy, University of Manchester, England. He was both Assistant Professor (1967-1971) and Associate Professor (1971-1975) of Pharmacy and Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco. Professor Rowland received his B.Pharm. (1961), Ph.D. (1965) and D.Sc. (1978) from University of London. His main research interests are basic and theoretical aspects of pharmacokinetics, especially physiologic pharmacokinetics. He is the author of over 200 research articles, reviews and book chapters, and is an editor of the Journal of Pharmacokinetics and Biopharmaceutics. Together with Dr. T. N. Tozer, Professor Rowland has written Clinical Pharmacokinetics: Concepts and Applications, 3rd, 1995.

 

LEWIS B. SHEINER

Lewis B. Sheiner is Professor of Laboratory Medicine, Pharmacy, and Medicine at the University of California, San Francisco, California. He received the MD degree from Albert Einstein College of Medicine in 1964, and did postgraduate medical and research training at Presbyterian Hospital (Columbia College of Physicians and Surgeons, New York - 1964-66), the NIH (National Institutes of Mental Health, and the Division of Computer Research and Technology - 1966-69) and Stanford University (1969-70). After two years of Clinical Pharmacology fellowship at UCSF (1970-72), he joined the faculty there, where he has since remained. His main research interests are pharmacokinetic/dynamic modelling and data analysis, especially as they concern observational population data. He is an author on more than 200 articles and book chapters, and is the editor of the Pharmacometrics section of the Journal of Pharmacokinetics and Biopharmaceutics.

Application Form

Total fee, including board and lodgings, and service: 3350 Swiss Francs.

The Workshop is limited to 50 applicants only. Ability to understand and converse in English is essential.

A limited number of places, at a reduced fee, are available to academic persons. Further details are available upon request to Professor M. Rowland.

If you would like an application form, please send your name and address to Ms Irene Sung at ISung@fs1.pa.man.ac.uk

 

Basic Workshop

For those who do not have the requisite background for the advanced workshop, and who wish to acquire it, a similarly structured workshop on basic approaches will be offered 5-10 July 1998 by the School of Pharmacy, University of Manchester. For information, please contact Ms Irene Sung, School of Pharmacy, University of Manchester, Manchester M13 9PL, England.

Phone: +44 (0)161-275-2348

Fax: +44 (0)161-273-8196

Email: ISung@fs1.pa.man.ac.uk

 

LOCATION OF WORKSHOP

Hotel Waldhaus (5 star), Sils-Maria, Engadin Valley, Switzerland. A picturesque and tranquil setting close to St. Moritz. The hotel has an indoor swimming pool and indoor tennis court.

 

ACCOMMODATION

Accommodation will be available through the nights of 22nd to 26th March 1998 at Hotel Waldhaus. Each room has a private bath room. The cost of accommodation is included in the Workshop.

 

ALL MEALS

All meals are included in the cost of the Workshop.

 

FREE TIME

The early afternoons are free for personal pursuits.

 

PUBLIC TRANSPORTATION

The Engadin Valley is readily reached by car. For those coming by air or rail there are regular trains to Sils-Maria from Zurich via Chur. Exact details and timetables will be sent to participants.

 

CAR PARKING

A car park is available within the grounds of Hotel Waldhaus.

 

FEE

Total fee, including board and lodgings, CHF3350 per person. Cancellation of a place will incur a charge of CHF200. Late cancellation may result in no refund.

 

FURTHER ENQUIRIES

To: Ms Irene Sung, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, England.

Phone: +44 (0) 161-275-2348

Fax: +44 (0) 161-273-8196

Email: ISung@fs1.pa.man.ac.uk

 

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