Research
Bioorganic phosphorus chemistry:
Synthesis and evaluation of
biologically active inositol phosphates
Prodrug methodology for the
cellular delivery of drugs containing phosphate or phosphonate groups
Synthesis and evaluation of carbohydrate phosphate analogues
Synthesis of
inhibitors and alternative substrates for enzymatic reactions
Teaching
Organic and medicinal chemistry
Administration
Secretary of Staff / UG Student committee
President of the Manchester
University Pharmaceutical Society
Member of the Postgraduate Affairs Group
Member of the Lister Institute
Qualifications
BSc Chemistry (Hons) First Class, Leicester University, 1982
PhD,
Organophosphorus Chemistry, Leicester University, 1985
Society Membership
Royal Society of Chemistry, CChem, MRSC
Brief Career Details
Lecturer and Lister Fellow in Medicinal Chemistry, Department of Pharmacy
(1994 - present)
Lecturer and Lister Fellow, Department of Pharmaceutical
Sciences, Aston University (1987 - 1994)
Visiting scientist, Cancer
Research Institute and Department of Chemistry (Professor GR Pettit), Arizona
State University, USA (1994)
Visiting scientist, Department of Chemistry
(Professor JR Knowles), Harvard University, USA
( 1988 - 1991)
Postdoctoral fellow, Department of Chemistry (Professor JR Knowles), Harvard
University, USA ( 1985 - 1987)
Awards
Dunlop Polymer Prize (1982)
Lilly Prize for Pharmaceutical Excellence
(1993)
Recent Publications
Spiers ID, Barker CJ, Chung S-K, Chang Y-T, Freeman S, Gardiner JM, Hirst
PH, Lambert PA, Michell RH, Poyner DR, Schwalbe CH, Smith AW, Solomons KRH.
Synthesis
and iron binding studies of myo-inositol 1,2,3-trisphosphate and
D/L-myo-inositol 1,2-bisphosphate, and iron binding studies of all myo-inositol
tetraphosphates.
Carbohydr. Res, 1996, 282, 81-89
Spiers ID, Freeman S, Schwalbe CH.
Crystal structure and modelling
studies of myo-inositol 1,2,3-trisphosphate.
J. Chem. Soc. Chem. Commun.,
1995, 2219-2220.
Routledge A, Walker I., Freeman S, Hay A, Mahmood N.
Synthesis,
bioactivation and anti-HIV activity of 4-acyloxybenzyl bis(nucleosid-5'-yl)
phosphates.
Nucleosides and Nucleotides, 1995, 14, 1545-1558.
Chawla S, Dixon HBF, Freeman S, Smith AW.
Synthesis of 3-arsonopyruvate
and its interaction with phosphoenolpyruvate mutase.
Biochem. J., 1995, 308,
931-935.
Pettit GR, Freeman S, Simpson MJ, Thompson MA, Boyd MR, Williams MD, Pettit
III GR, Doubek DL.
Antineoplastic agents 320: Synthesis of a practical
pancratistatin prodrug.
Anticancer Drug Design, 1995, 10, 243-250.
Spiers ID, Freeman S, Poyner DR, Schwalbe CH.
The first synthesis and iron
binding studies of the natural product, myo-inositol 1,2,3-trisphosphate.
Tetrahedron
Letters, 1995, 36, 2125-2128.
Ross KC, Rathbone DL, Thomson W, Freeman S.
Use of
bis[2-(trialkylsilyl)ethyl] N,N-dialkylphosphoramidities for the synthesis of
phosphate monoesters.
J. Chem. Soc., Perkin Trans. 1, 1995, 421-426.
Further Information
Tel: +44 (0)161 275 2366
FAX: +44 (0)161
275 2396
E-mail:
SFreeman@fs1.pa.man.ac.uk