Research
The molecular basis of drug action and the design of novel drugs
In
particular I am interested in the antibacterial and antiparasitic action of
polyketide inhibitors of protein biosynthesis
Techniques used include:
NMR spectroscopy
Isotopic labelling
Protein engineering and
expression
Protein chemistry
Molecular modelling
In collaboration
with groups at UMIST and Daresbury my group is involved with electrospray mass
spectrometry and circular dichroism spectroscopy
Teaching
Antibiotic action
Spectroscopy
Basic biochemistry
Administration
Elected member of Senate
Member of University Committee for Policy on
Undergraduate Education
Member of Faculty Review Committee
Secretary of
Departmental Genetic Manipulation Committee
Member of Departmental Safety
Committee
Member of Departmental Teaching and Examinations Committee
Senior
Internal Examiner for Medicinal Chemistry
Supervisor for Departmental NMR
Facility
Qualifications
B.A. (Hons) Natural Sciences, University of Cambridge, 1977
M.A. 1981
Ph.D.
Bio-organic Chemistry, University of Cambridge, 1980
M.A., D.Phil.,
University of Oxford (by incorporation), 1984
M.R.S.C., C.Chem. 1986
Society Membership
Royal Society of Chemistry
Biochemical Society
Brief Career Details
Senior Lecturer, Department of Pharmacy, 1993 - present
Lecturer, 1986 -
93
Demonstrator, Department of Biochemistry, University of Oxford, 1983 - 5.
Post-doctoral
research associate, Department of Nuclear Medicine, University of Heidelberg,
1982 - 83
Post-doctoral fellow, Department of Organic Chemistry, University
of Karlsruhe, 1980 - 82
Recent Publications
The 1H and 13C NMR Spectra of Spiramycin I in Organic and Aqueous Solutions
P.
Alam, J. Barber, R.J. Brennan, K. Kennedy and M.H.H. Tehrani
Magn.
Reson. Chem. (1995), 33, 228-231
Structural Studies on Erythromycin A Enol Ether: Full Assignments of the 1H
and 13C NMR Spectra
P. Alam, P.C. Buxton, J.A. Parkinson and J. Barber
J.
Chem. Soc. Perkins Trans. 2 (1995), 1163-1167
Conformational Analysis of the Erythromycin Analogues Azithromycin and
Clarithromycin in Aqueous Solution and Bound to Bacterial Ribosomes
A.
Awan, R.J. Brennan, A.C. Regan and J. Barber
J. Soc. Chem. Commun.
(1995), 1653-1654
Conformational Analysis
J. Barber and B. Wood
Chapter 11 in "Specialist
Periodical Reports, Nuclear Magnetic Resonance" vol. 24, Ed. G.A. Webb,
Royal Society of Chemistry, 362-397
The Antimalarial Activity of Berberine and Some Synthetic Analogues
N.
Silikas, D.L.C. McCall, D. Sharples, W.M. Watkins, R.D. Waigh and J.
Barber
Pharm. Sci. (1996), 2, 55-58
Further Information
Tel:. +44 (0) 161 275 2369
Fax: +44 (0) 161 275 2396
E-mail Jill.Barber@man.ac.uk