From: James Fullton <fullton>
Date: Fri, 26 Jul 91 11:23:22 EDT

$$XID NIHGUIDE 19910405 V20N14 P1O1 ************************************
X-comment: RFAs described: HL-91-05-H, HG-91-01
 
NIH GUIDE - Vol. 20, No. 14, April 5, 1991
 
$$INDEX BEGIN **********************************************************
 
                                   NOTICES
 
$$INDEX N1 *************************************************************
 
HUMAN LIVER CELL CULTURE FACILITY
National Institute of Diabetes and Digestive and Kidney Diseases
Index:  DIABETES, DIGESTIVE DISEASES, KIDNEY DISEASES
 
$$INDEX N2 *************************************************************
 
NATIONAL WORKSHOPS ON "PROTECTION OF HUMAN SUBJECTS"
National Institutes of Health
Food and Drug Administration
Index:  NATIONAL INSTITUTES OF HEALTH
        FOOD AND DRUG ADMINISTRATION

                   NOTICES OF AVAILABILITY (RFPs AND RFAs)
 
$$INDEX R1 *************************************************************
 
PROGRESSION OF JUVENILE PERIODONTITIS IN THE U.S.A. AND ASSOCIATED
RISK MARKERS (RFP)
National Institute of Dental Research
Index:  DENTAL RESEARCH
 
$$INDEX R2 *************************************************************
 
ORAL IRON CHELATOR TOXICITY IN ANIMALS (RFP)
National Institute of Diabetes and Digestive and Kidney Diseases
Index:  DIABETES, DIGESTIVE DISEASES, KIDNEY DISEASES
 
$$INDEX R3 09/06/91 ****************************************************
 
CELL LINES FOR HYPERTENSION RESEARCH (RFA HL-91-05-H)
National Heart, Lung, and Blood Institute
Index:  HEART, LUNG, BLOOD
 
$$INDEX R4 06/07/91 ****************************************************
 
STUDIES OF TESTING AND COUNSELING FOR CYSTIC FIBROSIS MUTATIONS
(RFA HG-91-01)
National Center for Human Genome Research
National Center for Nursing Research
National Institute of Child Health and Human Development
National Institute of Diabetes and Digestive and Kidney Diseases
Index:  HUMAN GENOME, NURSING RESEARCH, CHILD HEALTH, HUMAN
        DEVELOPMENT, DIABETES, DIGESTIVE DISEASES, KIDNEY DISEASES
 
$$INDEX R5 06/12/91 ****************************************************
 
INSTITUTIONAL CLINICAL TRAINING GRANTS:  PROFESSIONAL TRAINING FOR
RACIAL/ETHNIC MINORITY AND DISADVANTAGED STUDENTS (RFA MH-91-09)
National Institute of Mental Health
Index:  MENTAL HEALTH

                        ONGOING PROGRAM ANNOUNCEMENTS
 
$$INDEX P1 *************************************************************
 
COMMUNITY SUPPORT RESEARCH DEMONSTRATION PROJECTS (PA-91-39)
National Institute of Mental Health
Index:  MENTAL HEALTH
 
$$INDEX END ************************************************************
 
                                   NOTICES
 
$$N1 BEGIN *************************************************************
 
HUMAN LIVER CELL CULTURE FACILTY
 
P.T. 34; K.W. 0780005, 0780015
 
National Institute of Diabetes and Digestive and Kidney Diseases
 
The National Institute of Diabetes and Digestive and Kidney
Diseases (NIDDK) announces the establishment of a Human
Liver Cell Culture Facility for the purpose of making human
hepatocytes more widely accessible to researchers.
 
NIDDK supports the acquisition of excess normal human livers
from organ transplant donors and the isolation and culture
of hepatocytes from these tissues.  Human liver cells in
high yield are being routinely prepared.  Quality control
data on initial viability, survival in culture, selected
liver specific functions, and donor information (e.g., age,
sex, race, and cause of death) are available.
 
The human liver cells can be used in the Facility by a
visiting investigator who is resident at the laboratory or
who comes only when cells are available.  In addition,
hepatocytes can be shipped as attached monolayer cultures
within 24 hours of isolation to an investigator's laboratory.
Selected experiments with human hepatocytes can be conducted
for researchers by Facility personnel, when time permits,
but the costs of these special assays are not covered by the
NIDDK support and must be reimbursed.  Facility personnel
are also available to train investigators in the preparation
and handling of human hepatocytes.
 
All United States researchers are eligible to obtain human
hepatocytes.  However, those whose studies can provide
additional characterizations of the cells or contribute to
the further development of this resource are especially
encouraged.  Research requests are reviewed and prioritized
by an advisory committee.  To obtain a proposal form or
additional information about the Facility contact:
 
Dr. Carol E. Green
SRI International
333 Ravenswood Avenue
Menlo Park, CA  94025
Telephone:  (415) 859-4083
FAX:  (415) 859-3342
 
$$N1 END ***************************************************************
 
$$N2 BEGIN *************************************************************
 
NATIONAL WORKSHOPS ON "PROTECTION OF HUMAN SUBJECTS"
 
P.T. 42; K.W. 0783005
 
National Institutes of Health
Food and Drug Administration
 
The National Institutes of Health (NIH) and the Food and
Drug Administration (FDA) are continuing to sponsor a series
of workshops on the responsibilities of researchers,
Institutional Review Boards (IRBs), and institutional
officials for the protection of human subjects in research.
The workshops are open to everyone with an interest in
research involving human subjects.  The meetings should be
of special interest to those persons currently serving or
about to begin serving as a member of an IRB.  Issues
discussed at these workshops are relevant to all other
Public Health Service agencies.  The current schedule
includes the following:
 
MIDWEST WORKSHOP
 
DATES: April 11-12, 1991
 
PLACE:
Ramada Inn, Lakeshore
4900 South Lake Shore Drive
Chicago, IL  60615
 
SPONSORS:
University of Chicago
970 East 58th Street
Chicago, IL  60637
 
Chicago State University
95th Street at King Drive
Chicago, IL  60628
 
REGISTRATION CONTACT:
Mr. Arnold L. Aronoff
Associate Director
Faculty and Administrative Services
University Research Administration
University of Chicago
970 East 58th Street
Chicago, IL  60637
Telephone:  (312) 702-8669
 
TOPIC:  Cultural Diversity, Ethics, and Research:  A
Workshop on Human Subject Protection
 
NIH/FDA have planned workshops on human subject protections
in other parts of the United States.  For further
information regarding these workshops contact:
 
Darlene Marie Ross
Executive Assistant for Education
Division of Human Subject Protections
Office for Protection from Research Risks
National Institutes of Health
9000 Rockville Pike (Bldg. 31, Room 5B59)
Bethesda, MD  20892
Telephone:  (301) 496-8101
 
$$N2 END ***************************************************************
 
                   NOTICES OF AVAILABILITY (RFPs AND RFAs)
 
$$R1 BEGIN NIH-NIDR-2-91-7R ********************************************
 
PROGRESSION OF JUVENILE PERIODONTITIS IN THE U.S.A. AND
ASSOCIATED RISK MARKERS
 
RFP AVAILABLE:  NIH-NIDR-2-91-7R
 
P.T. 34; K.W. 0715148, 1002027, 0765035, 0413001
 
National Institute of Dental Research
 
The National Institute of Dental Research (NIDR) has a requirement
for a three-year, follow-up study of the NIDR Survey of
Oral Health of United States Children that was carried out in 1986-1987.
The analysis of data from the survey identified a number of
individuals with juvenile periodontitis.  The objectives of this
proposed project are:  (1) to assess the progression of
periodontal destruction among the cases of juvenile periodontitis,
(2) to characterize the microbial ecology of the subgingival
plaque, (3) to describe periodontal destruction and the presence
of biologic and non-biologic putative risk markers among the
probands' similar aged siblings, and (4) to compare the presence
and concentration of selected putative pathogens, host-resistance
factors, and non-biologic factors among individuals with juvenile
periodontitis to individuals without the disease, controlling for
demographic or other confounding variables.
 
This is an announcement for an anticipated Request for Proposals
(RFP).  RFP No. NIH-NIDR-2-91-7R will be available approximately
April 19, 1991, with a tentative closing date for proposals
set for June 3, 1991.  Requests for the RFP must be submitted in
writing to:
 
Marion L. Blevins
Contract Management Section
National Institute of Dental Research
National Institutes of Health
Westwood Building, Room 521
Bethesda, MD  20892
 
$$R1 END ***************************************************************
 
$$R2 BEGIN NIH-NIDDK-91-5 **********************************************
 
ORAL IRON CHELATOR TOXICITY IN ANIMALS
 
RFP AVAILABLE:  NIH-NIDDK-91-5
 
P.T. 34; K.W. 1007009, 0715032, 0740020
 
National Institute of Diabetes and Digestive and Kidney Diseases
 
The National Institute of Diabetes, and Digestive
and Kidney Diseases (NIDDK), Division of Kidney, Urologic,
and Hematologic Diseases, is seeking to procure the
preclinical toxicologic evaluation of selected oral iron
chelating compounds for use in the safe and effective
removal of iron deposits in patients with iron overload
condition (e.g., Cooley's Anemia and orphan diseases).
A clinical evaluation is not desired at this time.  The
contractor shall conduct toxicologic and related studies
of selected iron chelating compounds in rats, dogs, and
other animals, as directed by the Government, and shall
provide resulting toxicologic information to the NIDDK for
use in preparing submissions to the Food and Drug
Administration for approval of eventual clinical studies.
The drugs under development are considered to be orphan
drugs.  This Request for Proposals (RFP) NIH-NIDDK-91-5, will
be issued on or about April 11, 1991, with a closing date
set for May 29, 1991.
The NIDDK expects to award one contract from this solicitation.
 
To receive a copy of this RFP, please supply this office
with two self-addressed mailing labels and cite the RFP
number referenced above.  Requests must be in writing and
addressed to:
 
Mrs. Linda Cameron
Contract Specialist
Contracts Management Branch
National Institute of Diabetes and Digestive and Kidney Diseases
National Institutes of Health
Westwood Building, Room 602
5333 Westbard Avenue
Bethesda, MD  20892
 
Telephone requests will not be honored.
 
This advertisement does not commit the Government to make
an award.
 
$$R2 END ***************************************************************
 
$$R3 BEGIN HL-91-05-H FULL-TEXT ****************************************
 
CELL LINES FOR HYPERTENSION RESEARCH
 
RFA AVAILABLE:  HL-91-05-H
 
P.T. 34; K.W. 0715115, 0780015, 1002004, 1002008
 
National Heart, Lung, and Blood Institute
 
Application Receipt Date:  September 6, 1991
 
The Division of Heart and Vascular Diseases, National Heart,
Lung, and Blood Institute (NHLBI), announces the availability of
a Request for Applications (RFA) on the above subject.  The
purpose of this RFA is to encourage research, using both the
conventional and molecular approaches, to develop and
characterize primary or immortalized cell lines applicable to the
study of hypertension.  Particular emphasis is placed on
maintenance of the phenotype of cells derived from adrenal,
renal, endothelial, and other vascular cell types.  Specific
phenotypes include hormone production and/or reponsiveness,
transport functions, expression of key structural genes, or other
properties relevant to the study of blood pressure.
 
The Public Health Service (PHS) is committed to achieving the
health promotion and disease prevention objectives of Healthy
People 2000, a PHS-led national activity for setting priority
areas.  This RFA, "Cell Lines for Hypertension Research", is
related to the priority area of Heart Disease and Stroke.
Potential applicants may obtain a copy of "Healthy People 2000"
(Full Report:  Stock No. 017-001-00474-0) or "Healthy People
2000" (Summary Report:  Stock No. 017-001-00473-1) through the
Superintendent of Documents, Government Printing Office,
Washington, D.C. 20402-9325 (telephone 202-783-3238).
 
MECHANISM OF SUPPORT
 
The support mechanism for this program will be the traditional,
individual research grant.  Although approximately $1.25 million
in total costs for this program is included in the financial
plans for fiscal year 1992, award of grants pursuant to this RFA
is contingent upon receipt of funds for this purpose.  It is
anticipated that 5 grants will be awarded under this program.
The specific number to be funded, however, will depend on the
merit and scope of the applications received and the availability
of funds.
 
SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND MINORITIES IN
CLINICAL RESEARCH STUDIES
 
For projects involving clinical research, NIH requires applicants
to give special attention to the inclusion of women and
minorities in study populations.  If women or minorities are not
included in the study populations for clinical studies, a
specific justification for this exclusion must be provided.
Applications without such documentation will not be accepted for
review.
 
Inquiries  regarding  this  program  and  requests  for  the
complete RFA document should be addressed to:
 
Michael C. Lin, Ph.D
Hypertension and Kidney Diseases Branch
Division of Heart and Vascular Diseases
National Heart, Lung, and Blood Institute
Federal Building, Room 4C10
National Institutes of Health
Bethesda, MD  20892
Telephone:  (301) 496-1857
Fax:  (301) 496-9882
 
For fiscal and administrative matters, contact:
 
Jane R. Davis
Grants Operations Branch
Division of Extramural Affairs
National Heart, Lung, and Blood Institute
Westwood Building, Room 4A15C
Bethesda, MD  20892
Telephone:  (301) 496-7255
 
$$R3 END ***************************************************************
 
$$R4 BEGIN HG-91-01 FULL-TEXT ******************************************
 
STUDIES OF TESTING AND COUNSELING FOR CYSTIC FIBROSIS
MUTATIONS
 
RFA AVAILABLE:  HG-91-01
 
P.T. 34; K.W. 1002019, 1002028, 0404021, 0414014
 
National Center for Human Genome Research
National Center for Nursing Research
National Institute of Child Health and Human Development
National Institute of Diabetes and Digestive and Kidney Diseases
 
Letter of Intent Receipt Date:  May 1, 1991
Application Receipt Date:  June 7, 1991
 
The National Center for Human Genome Research, the National
Center for Nursing Research, the National Institute of Child
Health and Human Development, and the National Institute of
Diabetes and Digestive and Kidney Diseases invite applications
for assistance awards for studies of the clinical delivery of
educational and counseling services for individuals and families
related to DNA-based testing for the genetic mutations that cause
cystic fibrosis.
 
BACKGROUND
 
Given the pace of advances in human genetics, there is a
special need for clinical studies that use cystic fibrosis
(CF) carrier testing to develop generic models for the long-
range integration of genetic services into health care.  CF
is one of the most common autosomal recessive disorders, with
a carrier frequency of about 1 in 25 among United States
citizens of European ancestry.  An increasing range of
mutations responsible for the disease are now being
identified, making it possible to detect a high percentage of
those at risk of having children with CF.  The purpose of
such CF carrier testing would be to better inform interested
people of their reproductive health risks.  However,
evaluations of alternative approaches to genetic education,
testing, and counseling are needed in order to establish the
professional practices that should govern the provision of
DNA-based testing for CF carrier status.  Recent experience
with the widespread introduction of other genetic tests
suggests the value of such studies in helping to establish
practices that would improve professional interpretation and
patient understanding of CF testing and test results.
 
RESEARCH GOALS
 
The purpose of this Request for Applications (RFA) is to solicit
research projects that identify clinical practices that best
increase patient understanding of disease-gene carrier testing
and test results, and best protect individuals and families from
test-related psychological harm, stigmatization, and
discrimination.  Research questions that are appropriately
addressed in applications responding to this RFA could include,
but are not limited to:
 
o What are the levels of understanding of and interest in CF
carrier testing among different populations?
 
o What are the optimum forms and levels of pre-test
education for different populations?
 
o What post-test counseling strategies are most effective
in terms of the understanding and psychological health of
individuals and families?
 
o What are the optimum settings for providing CF carrier
testing services?
 
o What record-keeping and reporting policies best protect
against breaches of confidentiality, stigmatization, and
discrimination?
 
o What are the accuracy and cost effectiveness of various
types of tests?
 
Applications responding to this RFA need not attempt to
address all of these research questions.  For all approaches
assessed, however, questions of relative effectiveness,
relative costs, and relative ability to meet the demand for
services need to be evaluated.
 
SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND MINORITIES IN
CLINICAL RESEARCH STUDIES
 
For projects involving clinical research, NIH requires applicants
to give special attention to the inclusion of women and
minorities in study populations.  If women or minorities are not
included in the study populations for clinical studies, a
specific justification for this exclusion must be provided.
Applications without such documentation will not be accepted for
review.
 
MECHANISM OF SUPPORT
 
The RFA is a one-time solicitation for applications for
research project grants (R01).  The award period will be for
up to three years and is renewable.  It is anticipated that
$1 million will be available during fiscal year 1991 for
approximately five studies, although the number of awards is
contingent upon the quality, scope, and cost of the
applications received and the actual availability of
appropriated funds.
 
REVIEW PROCEDURES AND AWARD CRITERIA
 
Applications submitted in response to this RFA will be
reviewed in accordance with the usual NIH peer review
procedures.  The applications will be reviewed for scientific
merit by an initial review group (IRG) organized for this
purpose by the Office of Scientific Review, National Center
for Human Genome Research.  A second-level review will be
conducted by the appropriate national advisory council.
Funding decisions will be based on the recommendations of the
IRG and the advisory council regarding the scientific merit
and program relevance of the proposed research.
 
In order to make reliable comparisons possible between
studies, it is desirable that the research teams eventually
supported under this RFA work together to coordinate their
efforts.  To facilitate such coordination, grantee workshops
will be arranged after awards have been made.  The willingness
of applicants to participate in such planning and their
ability to contribute uniquely to the mix of studies will be
considered before an award is made.
 
FULL RFA AND LETTER OF INTENT
 
Prospective applicants should request and review a copy of
the full RFA from the program staff, and then submit a letter
of intent by May 1, 1991.  This letter should identify the
key personnel and include a descriptive title of the
proposed research.  The letter of intent is requested in order
to provide an indication of the number and scope of
applications to be reviewed.  The letter of intent does not
commit the sender to submit an application, nor is it a
requirement for submission of an application.  Please send
letters of intent and requests for the full RFA or additional
information to:
 
Eric T. Juengst, Ph.D.
Program Director
Ethical, Legal and Social Implications Program
National Center for Human Genome Research
National Institutes of Health
Building 38A, Room 612
Bethesda, MD  20892
Telephone:  (301) 496-7531
E-mail:  [email-masked]
 
For information about PHS Grants Policy, applicants may
contact:
 
Ms. Alice Thomas
Chief, Grants and Contracts Management
National Center for Human Genome Research
National Institutes of Health
Building 38A, Room 613
Bethesda, MD  20892
Telephone:  (301) 402-0733
 
This program is described
in the Catalog of Federal Domestic Assistance 93.865,
Research for Mothers and Children.
Awards will be made under the authority of the Public Health
Service Act, Section 301 and title 4 (Public Law 78-410, as
amended 42 U.S.C. 241 and 284) and administered under PHS
grants policies and Federal Regulations 42 CFR Part 52 and 45
CFR Part 74.  This program is not subject to the
intergovernmental review requirement of Executive Order 12372
or to Health Systems Agency review.
 
$$R4 END ***************************************************************
 
$$R5 BEGIN MH-91-09 ****************************************************
 
INSTITUTIONAL CLINICAL TRAINING GRANTS:  PROFESSIONAL
TRAINING FOR RACIAL/ETHNIC MINORITY AND DISADVANTAGED
STUDENTS
 
RFA AVAILABLE:  MH-91-09
 
P.T. 44, FF; K.W. 0720005, 0715095, 0715129, 0414000, 0414004, 0785185
 
National Institute of Mental Health
 
Application Receipt Date:  June 12, 1991
 
INTRODUCTION
 
Racial and ethnic minorities are soon expected to
become one-quarter of the United States population.
Projections are that the need for mental health
services will rise proportionately, particularly in the
public sector where most minority persons are served.
There is also increasing evidence that when minority
persons require mental health services they most often
seek mental health professionals of a race or ethnicity
similar to their own or choose settings staffed by
mental health professionals who demonstrate
responsiveness to their needs.  Currently, minorities
represent less than 10 percent of mental health
professionals.  The need to increase the numbers of
racial and ethnic minority mental health professionals
is clear so that they may serve not only their own
communities but also contribute to improving the
overall quality of the mental health system by
promoting its responsiveness to the unique needs of
culturally diverse groups.
 
The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000",
a PHS-led national activity for setting priority areas.  This RFA,
"Institutional Clinical Training Grants:  Professional Training for
Racial/Ethnic Minority and Disadvantaged Students,"
is related to the priority area of mental health and disorders.
Potential applicants may obtain a copy of "Healthy People 2000"
(Full Report:  Stock No. 017-001-00474-0) or "Healthy People 2000"
(Summary Report:  Stock No. 017-001-00473-1) through the
Superintendent of Documents, Government Printing Office,
Washington, D.C. 20402-9325 (telephone 202-783-3238).
 
PURPOSE
 
This program is designed to support recruitment and
education of racial/ethnic minority and disadvantaged
students to become professionals in the core mental
health disciplines of social work, psychiatric nursing,
psychology, psychiatry, and marriage and family
therapy.  The term "minority" in this announcement
refers to Blacks, Hispanics, Asian/Pacific Islanders
(including Native Hawaiians and Samoans), and American
Indians/Alaska Natives.  The definition of
disadvantaged students is left to the applicant
institution to justify.  It could include
the hearing impaired or those with other handicapping
conditions but would not extend to individuals whose
sole disadvantage is economic.
 
TRAINING ISSUES
 
For these students, the National Institute of Mental
Health (NIMH) offers clinical training programs that
are intended to enhance the quality and effectiveness
of services to persons with major mental disorders.
Applicants under this Request for Applications (RFA) must focus
in depth on one or
more of the priority populations described below.
Programs must demonstrate that they incorporate the
latest diagnostic and treatment procedures and the
latest relevant research findings.
 
The priority service populations for this RFA are:
 
o  Severely and persistently mentally ill adults
 
o     Children and adolescents with severe mental
disorders
 
o     Elderly with mental disorders
 
o     Mentally ill in rural areas
 
o     Racial/ethnic minorities with mental disorders
 
Other cross-cutting priorities are linkages between
academic programs and State/community service systems,
i.e., public-academic linkages and linkages with
clinical researchers and research trainers.
 
ELIGIBILITY
 
Accredited and/or approved departments/divisions in the
mental health core disciplines of psychiatric nursing,
psychiatry, psychology, social work, and marriage and
family therapy in colleges or universities of the
United States, including territories and possessions,
are eligible to apply.  Multidisciplinary applications
are encouraged.  Applications may be for predoctoral
and/or postdoctoral training in any of these fields.
 
APPLICATION CHARACTERISTICS
 
Applications must include a brief description of the
applicant educational institution and, if
appropriate, associated service and clinical research
settings, including background, history, programmatic
focus, organization, resources, personnel, and record
of educational/service/research linkage achievements.
 
Each application must include descriptions of:
 
o     the pool from which minority and/or disadvantaged
trainees will be recruited, recruitment strategies,
selection criteria
 
o     goals and objectives of the training
 
o     curricula content that addresses ethnic and
cultural issues
 
o     specific steps to be taken for the recruitment,
retention, and graduation of minority and/or
disadvantaged trainees
 
o     key faculty members and clinical supervisors
 
TERMS AND CONDITIONS OF SUPPORT
 
In fiscal year 1991, approximately $1.0 million will be
available to fund approximately 10 to 15 awards under
this RFA.  Support may be requested for up to three years.
Awards will be limited to a maximum of $80,000 (total costs), with
the exception of multidisciplinary awards that may be
funded up to $120,000 (total costs).
 
Payback Provisions
 
Any trainee who receives a clinical traineeship in
psychology, psychiatry, psychiatric nursing, social
work, or marriage and family therapy, in an established
training program, designed to be for a period of 180
days or more under an NIMH clinical training grant,
must pay back a period of obligated service equal to
the length of the traineeship.
 
APPLICATION PROCEDURES
 
Prospective applicants are strongly encouraged to
consult NIMH staff regarding eligibility and assistance
in developing applications.
Applications kits (PHS 398, rev. 10/88) containing the
necessary forms and Special Instructions may be
obtained by contacting the Education and Training
Branch staff listed at the end of this announcement.
 
REVIEW OF APPLICATIONS
 
A dual review system is used to ensure expert, objective review
of the quality of applications.  The first step, peer review for
educational and technical merit, is by primarily non-Federal
experts comprising initial review groups (IRGs).  The final
review is by the National Advisory Mental Health Council.  Only
applications recommended for approval by the Council will be
considered for funding.
 
RECEIPT AND REVIEW SCHEDULE
 
                          National Advisory
Receipt of     Initial    Mental Health      Earliest
Application    Review     Council Review     Award Date
 
June 12, 1991    July        September      September 1
 
AWARD OF GRANTS
 
Awards will be made on the basis of the following
criteria:
 
o    quality of proposed education/training programs as
determined by the review process
 
o    balance among programs directed to the priority
populations, among the disciplines and, where
appropriate, among geographic, especially rural,
locations
 
o    availability of funds
 
STAFF CONSULTATION
 
Staff consultation on clinical training grants is
available from the following:
 
Lemuel B. Clark, M.D.
Chief
Education and Training Branch
Division  of Clinical Research
National Institute of Mental Health
5600 Fishers Lane, Room 7C-02
Rockville, MD  20857
Telephone:  (301) 443-5850
 
For fiscal and administrative matters, contact:
 
Stephen Hudak
Chief, Grants Management Section
National Institute of Mental Health
Parklawn Building, Room 7C23
5600 Fishers Lane
Rockville, MD  20857
Telephone:  (301) 443-4456
 
$$R5 END ***************************************************************
 
                        ONGOING PROGRAM ANNOUNCEMENTS
 
$$P1 BEGIN *************************************************************
 
COMMUNITY SUPPORT RESEARCH DEMONSTRATION PROJECTS
 
PA:  PA-91-39
 
P.T. 34; K.W. 0715129, 0403004, 0414014
 
National Institute of Mental Health
 
BACKGROUND
 
Since 1978, the National Institute of Mental Health (NIMH) Community
Support Program (CSP) has
been working with States and communities to promote the
development of the most appropriate and effective
comprehensive, community-based services and service
systems for adults with severe and persistent mental
disorders.  These efforts have been reinforced by the
recent statutory requirements of P.L. 99-660.
 
In fiscal years 1989 and 1990, NIMH issued a Request for
Applications for research demonstration projects to
increase knowledge in psychosocial rehabilitation, case
management, and crisis response services.  In fiscal year
1991, CSP is issuing a new Program Announcement to
support research demonstration projects in the broader
community support and rehabilitation services area.
 
The population of concern for CSP grants includes
individuals 18 years and over with a severe and
persistent mental disorder that seriously impairs
functioning in interpersonal relations, living
arrangements, or employment.  NIMH encourages researchers
to pay particular attention to studying effective
approaches for serving high-priority subgroups of the
population that include individuals with a severe and
persistent mental disorder who are elderly, homeless
or at risk of becoming homeless, live in rural areas, or
are members of ethnic minority groups (specifically,
American Indians or Alaskan Natives, Asian/Pacific
Islanders, Blacks, and Hispanics).
 
NIMH is interested in expanding the knowledge base on the
relative benefits and costs of different approaches to
organizing and providing community support services that
reduce fragmentation, increase client satisfaction with
services, sustain individuals in community settings,
improve their quality of life, and enhance their ability
to function as productively and independently in society
as possible.
 
RESEARCH ISSUES
 
The research issues listed below is not exhaustive; it
is expected that applicants will identify other important
topics.
 
o   The effectiveness of different approaches for
addressing the systemic and external factors that
influence the operation of community support systems,
such as mechanisms to coordinate clinical treatment,
rehabilitation services, informal supports, and
mainstream services
 
o   The comparative effectiveness of different strategies
for integrating families and consumers into system
improvement efforts
 
o   The relative efficacy of different models of case
management services (e.g., clinical case management
versus the minimal and coordination models,
clinically based versus rehabilitation-based models,
team versus individual models, provider-based versus
family-based models, consumer-staffed versus
professionally staffed) in helping individuals
achieve living, learning, working, and socialization
goals
 
o   The relative efficacy of various housing options
(e.g., structured special residential settings versus
normative integrated community housing with visiting
supports)
 
o   The comparative effectiveness of various community
residential alternatives for individuals with severe
mental disorders diverted or discharged from nursing
home placements in accordance with the legislative
requirements of the Omnibus Budget Reconciliation Act
of 1987
 
o   The differential effectiveness of alternative
approaches to providing psychosocial rehabilitation
services that assist individuals to acquire the
living, learning, working, and socialization skills
they need to function in the community
 
o   The differential effectiveness of alternative crisis
response services, including the tailoring needed for
various settings, as reflected by outcomes such as
timeliness of intervention, development of relevant
treatment plans, effective stabilization, appropriate
followup care, and maintenance of individuals in the
community
 
o   Comparative effectiveness of approaches to meeting
the special needs of family members and engaging them
in the rehabilitation process (e.g., providing
education, emotional support, and periodic respite
care and other supportive services where the
individual is living within the family environment;
developing professional/family/client collaboration;
assisting in transitioning the family member to more
independent housing)
 
o   Comparative effectiveness of different approaches to
providing self-help services (e.g., drop-in centers,
socialization clubs, and peer supports), employing
consumers within the formal mental health system
(e.g., case managers, mobile outreach teams, job
coaches, and residential staff), and incorporating the
consumer perspective in all aspects of rehabilitation
from philosophy and structure to the nature of
services and service providers
 
o   Consistent with the provisions and protections of the
Americans with Disabilities Act, the effectiveness
of different approaches for providing reasonable
accommodations in the workplace for an individual's
mental disorder (e.g., flexible leave policies, job
restructuring, part-time or modified work schedules,
adjustments to supervision, and specialized training)
 
o   The differential effectiveness of alternatives in
decreasing the use of involuntary interventions such
as inpatient or outpatient commitment and involuntary
medication (e.g., working with family members,
management of violent and other troublesome behavior,
early crisis intervention, consumer-run safe houses,
in-home assistance, peer supports, and temporary
placement in foster family care)
 
o   Comparative effectiveness of outreach and other
formal and informal services to individuals in rural
communities where there are few formal services
 
o   The relative effectiveness of approaches to assist
severely mentally ill individuals in the correctional
system such as diversion to community treatment;
training police, correctional guards, or parole
officers; or offering treatment and services to
individuals in jails and after release.
 
ELIGIBILITY
 
Only State mental health authorities are eligible to
apply for CSP Community Research Demonstration Grants.
It is expected, however, that the primary researcher will
be the Principal Investigator, and the State staff member
with project oversight responsibility will be the Project
Coordinator.  Women and minority investigators are
encouraged to apply.
 
SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND
MINORITIES IN CLINICAL RESEARCH STUDIES
 
For projects involving clinical research, ADAMHA requires
applicants to give special attention to the inclusion of
women and minorities in study populations.  If women and
minorities are not included in the study populations for
clinical studies, a specific justification for this
exclusion must be provided.  Applications without such
documentation will not be accepted for review.
 
MECHANISM OF SUPPORT
 
Support for this program will be through research
demonstration project grants (R18).  Support may be
requested for a period of up to three years (renewable for
subsequent periods).  In FY 1990, $2 million was
available to support six projects.  Annual awards will be
made subject to continued availability of funds and
progress achieved.  A competing continuation (i.e.,
renewal) application may be submitted before the end of
an approved period of support in order to request
additional funds to continue a project.
 
APPLICATIONS PROCEDURES
 
Applicants must use the grant application form PHS 398
(rev. 10/88).  The number and title of this Program
Announcement, "PA-91-39, Community Support Research
Demonstration Projects", must be typed in item number
2 on the face page of the PHS 398 application form.
 
Applications to be considered for fiscal year 1991
funding, with an expected start date of September 30,
1991, must be received (not post-marked) by June 1, 1991.
 
REVIEW PROCEDURES AND CRITERIA
 
Applications received under this announcement will be
assigned to an Initial Review Group (IRG) and a PHS
funding component in accordance with established PHS
Referral Guidelines.  Applications will receive a second-
level review by the appropriate National Advisory Council
whose review may be based on policy considerations as
well as scientific merit.  Only applications recommended
for approval by the Council may be considered for
funding.  Applications will be evaluated for the
significance of the service problem and study questions
to be addressed and the scientific quality and rigor of
the research design.
 
Applications submitted in response to this announcement
are subject to the intergovernmental review requirements
of Executive Order 12372, as implemented through
Department of Health and Human Service regulations at 45
CFR Part 100.
 
INQUIRIES
 
Neal Brown, Chief, or Frances Randolph, Dr.P.H.
Project Officer
Community Support Section
System Development and Community Support Branch
Division of Applied and Services Research
National Institute of Mental Health
Parklawn Building, Room 11C-22
5600 Fishers Lane
Rockville, MD  20857
Telephone:  (301) 443-3653
 
For fiscal and administrative matters, contact:
 
Stephen Hudak
Chief, Grants Management Section
National Institute of Mental Health
Parklawn Building, Room 7C23
5600 Fishers Lane
Rockville, MD  20857
Telephone:  (301) 443-4456
 
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