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Re: [SANET-MG] Press release regarding BSE and vCJD
Hi Neal,
I am enclosing below the reference and abstract of the article you
mentioned. The general conclusion is right that infection with a
weakened strain of CJD may protect against infection with a virulent
form. However, the article indicates that the effect is not through
immune system but through the prion system itself, as I understand the
article. sincerely, Joe Cummins
Science 21 October 2005; 310: 493-496 [DOI: 10.1126/science.1118155
Reciprocal Interference Between Specific CJD and Scrapie Agents in
Neural Cell Cultures
Noriuki Nishida,1,2 Shigeru Katamine,3 Laura Manuelidis1
Infection of mice with an attenuated Creutzfeldt-Jakob disease agent
(SY-CJD)
interferes with superinfection by a more virulent human-derived CJD
agent (FUCJD)
and does not require pathological prion protein (PrPres). Using a rapid
coculture system, we found that a neural cell line free of immune system
cells
similarly supported substantial CJD agent interference without PrPres.
In addition,
SY-CJD prevented superinfection by sheep-derived Chandler (Ch) and 22L
scrapie agents. However, only 22L and not Ch prevented FU-CJD infection,
even
though both scrapie strains provoked abundant PrPres. This relationship
between
particular strains of sheep- and human-derived agents is likely to
affect their
prevalence and epidemic spread.
Neal Van Milligen wrote:
Research conducted by scientists in the United States and Japan
reached the controversial conclusion that a virus may be responsible
for bovine spongiform encephalopathy and the human version, variant
Creutzfeldt-Jakob disease, and that injection of a mild dose of vCJD
may immunize humans against the full-blown disease.
Laura Manuelidis, a neurologist at Yale University, was co-author of
the study, which is published in the latest issue of the journal
Science. The researchers injected mice with low levels of infected
material, and found this protected cells from the more dangerous
strain, Manuelidis said.
 
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