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[SANET-MG] transgenic DNA from maize feed is in animal tissues
Transgenic DNA fragments from Cry1AB maize was detected in blood,
spleen,liver, kidney and muscles of piglets fed GM maize. However, the
method of isolating the cellular DNA, though very effective, did not
tell whether or not the transgenic DNA fragments were joined to
chromosomal DNA or whether they were free in the cells or their nuclei.
Earlier studies from Germany showed that bacterial viral DNA fragments
from food were inserted into the chromasomal DNA molecules of mammals .
Further work is needed to detect transgenic DNA integrated into the
cells chromosomes.
Finally, the report claimed that health risks from isolated DNA have
never been detected but that conclusion is wrong! Isolated bacterial DNA
or DNA fragments injected, inhaled or eaten are know to promote
inflammation and autoimmunity through the CpG stimulation of innate
immunity.There are hundreds of publications dealing with that effect.
Transgenic Research
ISSN: 0962-8819 (Paper) 1573-9368 (Online)
DOI: 10.1007/s11248-005-0009-5 Issue: Volume 14, Number 5
Date: October 2005
Pages: 775 - 784
Assessing the Transfer of Genetically Modified DNA from Feed to Animal
Tissues
Raffaele Mazza1, 2 , Mirko Soave1, Mauro Morlacchini3, Gianfranco Piva2
and Adriano Marocco1
(1) Instituto di Agronomia generale e Coltivazioni erbacee, Università
Cattolica S. Cuore, Via E. Parmense, 84, Piacenza, 29100, Italy
(2) Istituto di Scienze degli Alimenti e della Nutrizione, Università
Cattolica S. Cuore, Via E. Parmense, 84, Piacenza, 29100 , Italy
(3) Centro Ricerche per la Zootecnica e l'Ambiente (CERZOO), Loc,
Possessione di Fondo - S. Bonico, Piacenza, 29100, Italy
Received: 13 October 2004 Accepted: 17 June 2005
Abstract In Europe, public and scientific concerns about the
environmental and food safety of GM (Genetically Modified) crops
overshadow the potential benefits offered by crop biotechnology to
improve food quality. One of the concerns regarding the use of GM food
in human and animal nutrition is the effect that newly introduced
sequences may have on the organism. In this paper, we assess the
potential transfer of diet-derived DNA to animal tissues after
consumption of GM plants. Blood, spleen, liver, kidney and muscle
tissues from piglets fed for 35 days with diets containing either GM
(MON810) or a conventional maize were investigated for the presence of
plant DNA. Only fragments of specific maize genes (Zein, Sh-2) could be
detected with different frequencies in all the examined tissues except
muscle. A small fragment of the Cry1A(b) transgene was detected in
blood, liver, spleen and kidney of the animals raised with the
transgenic feed. The intact Cry1A(b) gene or its minimal functional unit
were never detected. Statistical analysis of the results showed no
difference in recovery of positives for the presence of plant DNA
between animals raised with the transgenic feed and animals raised with
the conventional feed, indicating that DNA transfer may occur
independently from the source and the type of the gene. From the data
obtained, we consider it unlikely that the occurrence of genetic
transfer associated with GM plants is higher than that from conventional
plants.
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