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[SANET-MG] berries to treat cancer



Earlier I circulated a paper showing that organic strawberries are more effective than conventionally grown strawberries in treating human cancer. The current study does not differentiate between organic and conventional berries but does point out that strawberries and black raspberries are most effective in treating cancer cells.
J. Agric. Food Chem., ASAP Article 10.1021/jf061750g S0021-8561(06)01750-X
Web Release Date: November 18, 2006

Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry Extracts Inhibit Growth and Stimulate Apoptosis of Human Cancer Cells In Vitro

Navindra P. Seeram,* Lynn S. Adams, Yanjun Zhang, Rupo Lee, Daniel Sand, Henry S. Scheuller, and David Heber

Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095

Received for review June 21, 2006. Revised manuscript received October 11, 2006. Accepted October 13, 2006. Funding for this project was partially provided by the California Strawberry Commission, (Watsonville, CA) and from the UCLA Center for Human Nutrition NCI Grant PO1CA42710.

Abstract:

Berry fruits are widely consumed in our diet and have attracted much attention due to their potential human health benefits. Berries contain a diverse range of phytochemicals with biological properties such as antioxidant, anticancer, anti-neurodegerative, and anti-inflammatory activities. In the current study, extracts of six popularly consumed berries-blackberry, black raspberry, blueberry, cranberry, red raspberry and strawberry-were evaluated for their phenolic constituents using high performance liquid chromatography with ultraviolet (HPLC-UV) and electrospray ionization mass spectrometry (LC-ESI-MS) detection. The major classes of berry phenolics were anthocyanins, flavonols, flavanols, ellagitannins, gallotannins, proanthocyanidins, and phenolic acids. The berry extracts were evaluated for their ability to inhibit the growth of human oral (KB, CAL-27), breast (MCF-7), colon (HT-29, HCT116), and prostate (LNCaP) tumor cell lines at concentrations ranging from 25 to 200 g/mL. With increasing concentration of berry extract, increasing inhibition of cell proliferation in all of the cell lines were observed, with different degrees of potency between cell lines. The berry extracts were also evaluated for their ability to stimulate apoptosis of the COX-2 expressing colon cancer cell line, HT-29. Black raspberry and strawberry extracts showed the most significant pro-apoptotic effects against this cell line. The data provided by the current study and from other laboratories warrants further investigation into the chemopreventive and chemotherapeutic effects of berries using in vivo models.

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