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[SANET-MG] berries to treat cancer
Earlier I circulated a paper showing that organic strawberries are more
effective than conventionally grown strawberries in treating human
cancer. The current study does not differentiate between organic and
conventional berries but does point out that strawberries and black
raspberries are most effective in treating cancer cells.
J. Agric. Food Chem., ASAP Article 10.1021/jf061750g S0021-8561(06)01750-X
Web Release Date: November 18, 2006
Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and
Strawberry Extracts Inhibit Growth and Stimulate Apoptosis of Human
Cancer Cells In Vitro
Navindra P. Seeram,* Lynn S. Adams, Yanjun Zhang, Rupo Lee, Daniel Sand,
Henry S. Scheuller, and David Heber
Center for Human Nutrition, David Geffen School of Medicine, University
of California, Los Angeles, California 90095
Received for review June 21, 2006. Revised manuscript received October
11, 2006. Accepted October 13, 2006. Funding for this project was
partially provided by the California Strawberry Commission,
(Watsonville, CA) and from the UCLA Center for Human Nutrition NCI Grant
PO1CA42710.
Abstract:
Berry fruits are widely consumed in our diet and have attracted much
attention due to their potential human health benefits. Berries contain
a diverse range of phytochemicals with biological properties such as
antioxidant, anticancer, anti-neurodegerative, and anti-inflammatory
activities. In the current study, extracts of six popularly consumed
berries-blackberry, black raspberry, blueberry, cranberry, red raspberry
and strawberry-were evaluated for their phenolic constituents using high
performance liquid chromatography with ultraviolet (HPLC-UV) and
electrospray ionization mass spectrometry (LC-ESI-MS) detection. The
major classes of berry phenolics were anthocyanins, flavonols,
flavanols, ellagitannins, gallotannins, proanthocyanidins, and phenolic
acids. The berry extracts were evaluated for their ability to inhibit
the growth of human oral (KB, CAL-27), breast (MCF-7), colon (HT-29,
HCT116), and prostate (LNCaP) tumor cell lines at concentrations ranging
from 25 to 200 g/mL. With increasing concentration of berry extract,
increasing inhibition of cell proliferation in all of the cell lines
were observed, with different degrees of potency between cell lines. The
berry extracts were also evaluated for their ability to stimulate
apoptosis of the COX-2 expressing colon cancer cell line, HT-29. Black
raspberry and strawberry extracts showed the most significant
pro-apoptotic effects against this cell line. The data provided by the
current study and from other laboratories warrants further investigation
into the chemopreventive and chemotherapeutic effects of berries using
in vivo models.
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